Rao Mayuree, DePue Judith D, Dunsiger Shira, Elsayed Mohammad, Nu'usolia Ofeira, McGarvey Stephen T
Warren Alpert Medical School of Brown University, 222 Richmond St, Box G-9230A, Providence, RI 02903. Email:
Warren Alpert Medical School of Brown University, Providence, Rhode Island, and Centers for Behavioral and Preventive Medicine, Miriam Hospital, Providence, Rhode Island.
Prev Chronic Dis. 2015 Oct 22;12:E180. doi: 10.5888/pcd12.150160.
Diabetes Care in American Samoa (DCAS) was a randomized controlled trial of a 12-month intervention facilitated by community health workers (CHWs) that demonstrated improved HbA1c levels compared with usual care at trial completion. We sought to evaluate the long-term impact of this intervention on diabetes control.
We retrospectively collected HbA1c measurements from medical records of DCAS participants (n = 268). The study group received the intervention during the trial, and the control group received the intervention after the trial. We used mixed-effects longitudinal regression models to assess change in HbA1c within each trial arm during 3 time periods: DCAS (12 months of the study group's intervention), the first year after DCAS (control group's intervention), and the second year after DCAS. Models were adjusted for baseline characteristics that differed significantly for participants with a low number of HbA1c measurements from those with a high number of HbA1c measurements.
After adjustment for confounders, the experiment group experienced a decrease in HbA1c of 0.28 units per year (95% confidence interval [CI], -0.64 to 0.07) during DCAS (intervention). HbA1c decreased by 0.88 units per year (95% CI, -1.31 to -0.45) during the year after the intervention. No significant change was observed the following year. HbA1c of the control group did not significantly change during DCAS (usual care) but decreased by 1.31 units per year (95% CI, -1.72 to -0.91) during its intervention. During the year after the control group's intervention, HbA1c increased by 1.18 units per year (95% CI, 0.42 to 1.93).
Both groups had initial improvements in glycemic control, but HbA1c later plateaued or increased. These results suggest that time-limited CHW programs improve diabetes control in the short term, but ongoing programs are needed for sustained impact.
美属萨摩亚糖尿病护理(DCAS)是一项随机对照试验,由社区卫生工作者(CHW)推动进行为期12个月的干预,试验结束时与常规护理相比,糖化血红蛋白(HbA1c)水平有所改善。我们试图评估这种干预对糖尿病控制的长期影响。
我们回顾性收集了DCAS参与者(n = 268)病历中的HbA1c测量值。研究组在试验期间接受干预,对照组在试验后接受干预。我们使用混合效应纵向回归模型评估每个试验组在三个时间段内HbA1c的变化:DCAS(研究组干预的12个月)、DCAS后的第一年(对照组干预)和DCAS后的第二年。模型针对HbA1c测量次数少的参与者与测量次数多的参与者之间有显著差异的基线特征进行了调整。
在调整混杂因素后,实验组在DCAS(干预)期间HbA1c每年下降0.28个单位(95%置信区间[CI],-0.64至0.07)。干预后一年中,HbA1c每年下降0.88个单位(95%CI,-1.31至-0.45)。次年未观察到显著变化。对照组的HbA1c在DCAS(常规护理)期间无显著变化,但在其干预期间每年下降1.31个单位(95%CI,-1.72至-0.91)。在对照组干预后的一年中,HbA1c每年增加1.18个单位(95%CI,0.42至1.93)。
两组在血糖控制方面最初均有改善,但HbA1c后来趋于平稳或上升。这些结果表明,限时的社区卫生工作者项目在短期内可改善糖尿病控制,但需要持续开展项目以产生持续影响。