Alhadeff J A
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania.
Crit Rev Oncol Hematol. 1989;9(1):37-107. doi: 10.1016/s1040-8428(89)80014-9.
The cell surface is involved in cell growth and division, cell-cell interaction, communication, differentiation and migration, and other processes likely to be involved in malignant transformation and/or the metastatic spread of cancer. Although there are many alterations of glycoproteins and glycolipids on the malignant cell surface, it is unclear whether these alterations are epiphenomena or an integral part of the malignancy process. This article reviews the recent literature and some earlier studies relevant for understanding emerging concepts and trends with respect to malignant cell glycoconjugates. Emphasis is on structural alterations of the carbohydrate portions of malignant cell glycoproteins and glycolipids and on the enzymes (glycosyltransferases and glycosidases) involved in their metabolism. Practical applications derived from malignant cell glycoconjugate studies are discussed briefly with respect to the diagnosis, staging, monitoring, and treatment of malignant disease. The review concludes by indicating which research areas on malignant cell glycoconjugates are likely to be fruitful in increasing our basic understanding of, and ability to deal effectively with, malignant disease.
细胞表面参与细胞生长与分裂、细胞间相互作用、通讯、分化和迁移，以及其他可能与癌症的恶性转化和/或转移扩散相关的过程。虽然恶性细胞表面的糖蛋白和糖脂有许多改变，但尚不清楚这些改变是附带现象还是恶性过程的一个组成部分。本文综述了近期文献以及一些早期研究，这些研究对于理解与恶性细胞糖缀合物相关的新兴概念和趋势具有重要意义。重点在于恶性细胞糖蛋白和糖脂碳水化合物部分的结构改变，以及参与其代谢的酶（糖基转移酶和糖苷酶）。简要讨论了从恶性细胞糖缀合物研究中得出的实际应用，涉及恶性疾病的诊断、分期、监测和治疗。综述最后指出，恶性细胞糖缀合物的哪些研究领域可能有助于增进我们对恶性疾病的基本理解，并提高有效应对恶性疾病的能力。
