脑肿瘤病例中血清L-岩藻糖的评估。
Assessment of serum L-fucose in brain tumor cases.
作者信息
Manjula S, Monteiro Flama, Rao Aroor Annaya, Rao Suryanarayan, Annaswamy Raja, Rao Anjali
机构信息
Department of Biochemistry, Yenepoya Medical College, Mangalore, India.
出版信息
Ann Indian Acad Neurol. 2010 Jan;13(1):33-6. doi: 10.4103/0972-2327.61274.
BACKGROUND
Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors.
OBJECTIVE
The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor.
MATERIALS AND METHODS
Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride.
RESULTS
There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values.
CONCLUSION
Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.
背景
人类颅内肿瘤中，肿瘤细胞糖基化改变与细胞异质性的关系仍相对未被揭示。许多研究者报告称，血清蛋白结合碳水化合物L-岩藻糖在肿瘤进展过程中过度表达。因此，有必要确定糖蛋白升高在各种肿瘤病例中的诊断、预后和功能意义。
目的
本研究的目的是评估血清L-岩藻糖在脑肿瘤患者中的临床应用价值。
材料与方法
对99例脑肿瘤患者的血清糖缀合物水平进行了评估。采用温兹勒法，使用盐酸半胱氨酸通过比色法对L-岩藻糖进行测定。
结果
大多数患者的L-岩藻糖水平显著升高。在治疗后的病例中，L-岩藻糖水平明显低于术前值。
结论
我们的结果表明，血清L-岩藻糖的升高除了可作为其他标志物外，还可作为脑肿瘤的一个通用标志物。
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