Manjula S, Monteiro Flama, Rao Aroor Annaya, Rao Suryanarayan, Annaswamy Raja, Rao Anjali
Department of Biochemistry, Yenepoya Medical College, Mangalore, India.
Ann Indian Acad Neurol. 2010 Jan;13(1):33-6. doi: 10.4103/0972-2327.61274.
Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors.
The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor.
Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride.
There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values.
Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.
人类颅内肿瘤中，肿瘤细胞糖基化改变与细胞异质性的关系仍相对未被揭示。许多研究者报告称，血清蛋白结合碳水化合物L-岩藻糖在肿瘤进展过程中过度表达。因此，有必要确定糖蛋白升高在各种肿瘤病例中的诊断、预后和功能意义。
本研究的目的是评估血清L-岩藻糖在脑肿瘤患者中的临床应用价值。
对99例脑肿瘤患者的血清糖缀合物水平进行了评估。采用温兹勒法，使用盐酸半胱氨酸通过比色法对L-岩藻糖进行测定。
大多数患者的L-岩藻糖水平显著升高。在治疗后的病例中，L-岩藻糖水平明显低于术前值。
我们的结果表明，血清L-岩藻糖的升高除了可作为其他标志物外，还可作为脑肿瘤的一个通用标志物。
