Barkarmo S, Andersson M, Currie F, Kjellin P, Jimbo R, Johansson C B, Stenport V
Department of Prosthodontics, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Chemical and Biological Engineering, Applied Surface Chemistry, Chalmers University of Technology, Gothenburg, Sweden.
J Biomater Appl. 2014 Nov;29(5):737-47. doi: 10.1177/0885328214542854. Epub 2014 Jul 10.
To investigate the bone response to threaded polyetheretherketone (PEEK) implants coated with nanohydroxyapatite.
A total of 39 PEEK implants were coated with nanocrystalline hydroxyapatite and 39 uncoated implants were used as controls. The implant surface was characterized by optical interferometry and scanning electron microscope. The implants were inserted in the tibia and femur of 13 rabbits. After 6 weeks of healing, quantitative and qualitative analyses were performed.
The test implants showed significantly higher removal torque test values compared with the control group. Histomorphometric evaluation demonstrated higher bone-to-implant contact for the test implants; however, there were no differences in bone area between the groups. Qualitative histological analyses demonstrated inflammatory cellular reactions in close vicinity of both implant surfaces. A two-cell layer of foreign body giant cells was observed irrespective of sample type.
Our findings demonstrate that implants with a threaded design render good stability to PEEK in both coated and uncoated implants. Nanohydroxyapatite-coated PEEK implants demonstrated improved bone formation compared with uncoated controls.
研究纳米羟基磷灰石涂层的带螺纹聚醚醚酮（PEEK）种植体的骨反应。
总共39个PEEK种植体涂覆纳米晶羟基磷灰石，39个未涂覆的种植体用作对照。通过光学干涉测量法和扫描电子显微镜对种植体表面进行表征。将种植体植入13只兔子的胫骨和股骨中。愈合6周后，进行定量和定性分析。
与对照组相比，测试种植体的取出扭矩测试值显著更高。组织形态计量学评估显示测试种植体的骨-种植体接触更高；然而，两组之间的骨面积没有差异。定性组织学分析显示在两种种植体表面附近均有炎性细胞反应。无论样品类型如何，均观察到异物巨细胞的两层细胞。
我们的研究结果表明，带螺纹设计的种植体使涂覆和未涂覆的PEEK均具有良好的稳定性。与未涂覆的对照相比，纳米羟基磷灰石涂层的PEEK种植体显示出改善的骨形成。
