Chen Jung-Chien, Lee Wei-Jei, Tsou Jun-Juin, Liu Tsang-Pai, Tsai Pei-Ling
Division of General Surgery, Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC; Division of General Surgery, Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC; Department of Nursing, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC.
Division of General Surgery, Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan, ROC.
Surg Obes Relat Dis. 2016 Jan;12(1):57-61. doi: 10.1016/j.soard.2015.07.010. Epub 2015 Jul 18.
Gastric bypass surgery is the recommended treatment for severely obese patients. However, postoperative symptomatic gastrointestinal (GI) episodes are common complaints.
To determine if administration of probiotics improves symptomatic GI episodes after gastric bypass surgery.
Hospital-based bariatric center.
This double-blind, randomized trial was conducted between March 2010 and September 2010 with 60 patients who underwent gastric bypass for severe obesity and experienced postoperative symptomatic GI episodes. Patients were randomly assigned to the probiotics group A (n = 20; 1 g Clostridium butyricum MIYAIRI twice daily); probiotics group B (n = 20; Bifidobacterium longum BB536 twice daily); or digestive enzymes group (n = 20; Aczym, containing 100 mg takadiastase N, 20 mg cellulase AP, 50 mg lipase MY, and 100 mg pancreatin, twice daily). Quality of life was measured using the modified Gastrointestinal Quality of Life Index (mGIQLI) before and after the 2-week intervention.
Preintervention patient characteristics and mGIQLI scores were similar among the 3 groups. After the 2-week intervention, the mean mGIQLI score improved from 57.4 to 63.9 points in the entire sample and also within each group for 7 items specifically for 7: excessive passage of gas, foul smell of flatulence, belching, heartburn, abdominal noises, abdominal bloating, and abdominal pain.
Administration of probiotics or digestive enzymes may improve symptomatic GI episodes after gastric bypass surgeries and improve quality of life, at least initially.
胃旁路手术是重度肥胖患者的推荐治疗方法。然而，术后出现有症状的胃肠道（GI）发作是常见的主诉。
确定服用益生菌是否能改善胃旁路手术后有症状的胃肠道发作。
医院的减肥中心。
这项双盲随机试验于2010年3月至2010年9月进行，纳入60例因重度肥胖接受胃旁路手术且术后出现有症状的胃肠道发作的患者。患者被随机分配到益生菌A组（n = 20；每日两次，每次1 g丁酸梭菌MIYAIRI）；益生菌B组（n = 20；每日两次，每次长双歧杆菌BB536）；或消化酶组（n = 20；Aczym，含100 mg达吉淀粉酶、20 mg纤维素酶AP、50 mg脂肪酶MY和100 mg胰酶，每日两次）。在为期2周的干预前后，使用改良的胃肠道生活质量指数（mGIQLI）测量生活质量。
干预前，3组患者的特征和mGIQLI评分相似。经过2周的干预后，整个样本以及每组中专门针对7项症状（气体过度排出、肠胃气胀异味、嗳气、烧心、腹部咕噜声、腹胀和腹痛）的平均mGIQLI评分从57.4分提高到了63.9分。
服用益生菌或消化酶可能会改善胃旁路手术后有症状的胃肠道发作，并至少在初期改善生活质量。
