George Blassan Plackal Adimuriyil, Abrahamse Heidi
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, South Africa.
Anticancer Agents Med Chem. 2016;16(7):793-801. doi: 10.2174/1871520615666151026094028.
This review article presents an extensive examination of risk factors for breast cancer, treatment strategies with special attention to photodynamic therapy and natural product based treatments. Breast cancer remains the most commonly occurring cancer in women worldwide and the detection, treatment, and prevention are prominent concerns in public health. Background information on current developments in treatment helps to update the approach towards risk assessment. Breast cancer risk is linked to many factors such as hereditary, reproductive and lifestyle factors. Minimally invasive Photodynamic therapy (PDT) can be used in the management of various cancers; it uses a light sensitive drug (a photosensitizer, PS) and a light of visible wavelength, to destroy targeted cancer cells. State of the art analyses has been carried out to investigate advancement in the search for the cure and control of cancer progression using natural products. Traditional medicinal plants have been used as lead compounds for drug discovery in modern medicine. Both PDT and plant derived drugs induce cell death via different mechanisms including apoptosis, necrosis, autophagy, cell cycle regulation and even the regulation of various cell signalling pathways.
这篇综述文章对乳腺癌的风险因素进行了广泛研究，特别关注光动力疗法和基于天然产物的治疗策略。乳腺癌仍然是全球女性中最常见的癌症，其检测、治疗和预防是公共卫生领域的突出问题。有关当前治疗进展的背景信息有助于更新风险评估方法。乳腺癌风险与许多因素有关，如遗传、生殖和生活方式因素。微创光动力疗法（PDT）可用于多种癌症的治疗；它使用一种光敏药物（一种光致敏剂，PS）和可见波长的光来破坏靶向癌细胞。已进行了最先进的分析，以研究使用天然产物在寻找癌症治愈方法和控制癌症进展方面的进展。传统药用植物已被用作现代医学中药物发现的先导化合物。PDT和植物衍生药物都通过不同机制诱导细胞死亡，包括凋亡、坏死、自噬、细胞周期调节，甚至各种细胞信号通路的调节。
