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在过去十一年里，乳腺癌免疫原性细胞死亡领域是如何发展的，又对临床实践产生了怎样的影响？

How has the field of immunogenic cell death in breast cancer evolved and impacted clinical practice over the past eleven years?

作者信息

Deng Yu-Long, Chi Bang-Teng, Lu Shang-Yi, Xiong Dan-Dan, He Rong-Quan, Qin Di-Yuan, Huang Wan-Ying, Yang Xia, Chen Gang, Peng Wei, Luo Jiayuan

机构信息

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, P. R. China.

Department of Hepatological and Gland Surgery, Wuzhou Gongren Hospital/The Seventh Affiliated Hospital of Guangxi Medical University, Wuzhou, P. R. China.

出版信息

Hum Vaccin Immunother. 2025 Dec;21(1):2505349. doi: 10.1080/21645515.2025.2505349. Epub 2025 May 26.

DOI:10.1080/21645515.2025.2505349
PMID:40418649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12118423/
Abstract

This study elucidates the research landscape of immunogenic cell death (ICD) in breast cancer through a bibliometric analysis of 457 Web of Science articles. Contributions from China and the USA are particularly prominent, with notable international collaborations. Core journals such as published influential studies, while researchers like Huang Y made impactful contributions. High-frequency keyword analysis identified key research hotspots, including immunotherapy, the tumor microenvironment, and nanomedicine. The integration of chemotherapy with immunotherapy and the identification of key proteins have driven recent advancements. Fundamental research on immunotherapy, photodynamic therapy (PDT), and triple-negative breast cancer (TNBC) points to future trends and potential breakthroughs. This study offers a strategic overview of ICD in breast cancer, providing insights into clinical practice and guiding future research in the field.

摘要

本研究通过对457篇科学网文章进行文献计量分析，阐明了乳腺癌免疫原性细胞死亡（ICD）的研究概况。中国和美国的贡献尤为突出，有显著的国际合作。诸如《》等核心期刊发表了有影响力的研究，而像黄Y等研究人员也做出了有影响力的贡献。高频关键词分析确定了关键研究热点，包括免疫疗法、肿瘤微环境和纳米医学。化疗与免疫疗法的整合以及关键蛋白的鉴定推动了近期的进展。对免疫疗法、光动力疗法（PDT）和三阴性乳腺癌（TNBC）的基础研究指出了未来趋势和潜在突破。本研究提供了乳腺癌ICD的战略概述，为临床实践提供了见解，并指导该领域的未来研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/696dcbcb2355/KHVI_A_2505349_F0010_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/37cbf8371da5/KHVI_A_2505349_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/4865396ec12d/KHVI_A_2505349_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/70ba7c909be2/KHVI_A_2505349_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/94b645ceb365/KHVI_A_2505349_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/ec1189ba321a/KHVI_A_2505349_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/696dcbcb2355/KHVI_A_2505349_F0010_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/a6cf863242fb/KHVI_A_2505349_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/483b5144114b/KHVI_A_2505349_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/7d6a4fcf522c/KHVI_A_2505349_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/db0af89cc300/KHVI_A_2505349_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/37cbf8371da5/KHVI_A_2505349_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/4865396ec12d/KHVI_A_2505349_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/70ba7c909be2/KHVI_A_2505349_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/94b645ceb365/KHVI_A_2505349_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/ec1189ba321a/KHVI_A_2505349_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3064/12118423/696dcbcb2355/KHVI_A_2505349_F0010_OC.jpg

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本文引用的文献

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