Li Zhaoyong, Zhang Huafeng
Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.
Cell Mol Life Sci. 2016 Jan;73(2):377-92. doi: 10.1007/s00018-015-2070-4. Epub 2015 Oct 23.
Metabolic reprogramming is widely observed during cancer development to confer cancer cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting, conditions. It is famously known that cancer cells favor the "Warburg effect", i.e., the enhanced glycolysis or aerobic glycolysis, even when the ambient oxygen supply is sufficient. In addition, deregulated anabolism/catabolism of fatty acids and amino acids, especially glutamine, serine and glycine, have been identified to function as metabolic regulators in supporting cancer cell growth. Furthermore, extensive crosstalks are being revealed between the deregulated metabolic network and cancer cell signaling. These exciting advancements have inspired new strategies for treating various malignancies by targeting cancer metabolism. Here we review recent findings related to the regulation of glucose, fatty acid and amino acid metabolism, their crosstalk, and relevant cancer therapy strategy.
在癌症发展过程中广泛观察到代谢重编程，使癌细胞即使在诸如营养限制等应激条件下也具有存活和增殖的能力。众所周知，癌细胞倾向于“瓦伯格效应”，即即使在周围氧气供应充足时，糖酵解或有氧糖酵解也会增强。此外，已确定脂肪酸和氨基酸（尤其是谷氨酰胺、丝氨酸和甘氨酸）的合成代谢/分解代谢失调在支持癌细胞生长中起代谢调节作用。此外，失调的代谢网络与癌细胞信号传导之间正在揭示广泛的相互作用。这些令人兴奋的进展激发了通过靶向癌症代谢来治疗各种恶性肿瘤的新策略。在这里，我们综述了与葡萄糖、脂肪酸和氨基酸代谢调节、它们的相互作用以及相关癌症治疗策略有关的最新发现。
