Schwartz R H, Bogema S, Thorne M M
Fairfax Hospital, Falls Church, Va.
Arch Pathol Lab Med. 1989 Apr;113(4):363-4.
The Keystone Diagnostic Inc (KDI) Quik Test is advertised to be an on-site, rapid, broad-spectrum paper chromatography test that is marketed for use in industry, drug abuse treatment facilities, and physician's offices. Even when unskilled individuals perform the test, five drugs of abuse, excluding marijuana, are said by the manufacturer to be reliably detected. In this study, ten confirmed drug-free urine specimens and 56 specimens positive by an immunoassay screening test, and confirmed by gas chromatography/mass spectrometry, for cocaine (n = 32), phencyclidine (n = 12), or opiate drugs (n = 12), were reanalyzed by the KDI Quik Test. The sensitivity of the KDI Quik Test was 62.5%, specificity was 70%, predictive value of a negative test was 36%, and efficiency was 64%. In too many instances the KDI Quik Test did not detect the drugs for which it is intended. Paper chromatography tests such as the KDI Quik Test are inaccurate and as such are unacceptable in any setting for the purposes of screening for drugs of abuse.
基石诊断公司（KDI）快速检测试剂盒被宣传为一种现场即时、快速、广谱的纸色谱检测方法，面向工业、药物滥用治疗机构及医生办公室进行销售。即便由非专业人员操作该检测，制造商称其仍能可靠检测出除大麻外的五种滥用药物。在本研究中，对十份经确认不含药物的尿液标本以及56份经免疫分析筛查检测呈阳性、并经气相色谱/质谱法确认为可卡因（n = 32）、苯环利定（n = 12）或阿片类药物（n = 12）的标本，采用KDI快速检测试剂盒重新进行分析。KDI快速检测试剂盒的灵敏度为62.5%，特异性为70%，阴性检测预测值为36%，检测效率为64%。在太多情况下，KDI快速检测试剂盒未能检测出其宣称可检测的药物。像KDI快速检测试剂盒这样的纸色谱检测方法并不准确，因此在任何用于筛查滥用药物的场景中都不可接受。
