Ligong Zhang, Jinjin Qin, Chunfu Chen, Congcong Li, Xiaojun Diao
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
Med Sci Monit. 2015 Oct 28;21:3270-4. doi: 10.12659/msm.894666.
The aim of this study was to analyze the effects of obesity and leptin levels on patients with migraine, and to observe the change of leptin levels in migraineurs.
We enrolled 52 migraine patients from the Headache Clinic in Shandong Provincial Hospital into a randomized controlled trial with another 52 age-, sex-, and BMI-matched healthy subjects as controls. Leptin levels in all subjects were determined by radioimmunoassay.
Compared with the control group, the migraineurs revealed no significant change in leptin levels (P>0.05). Multivariate Logistic regression analysis showed that neither abdominal obesity nor leptin had significant impact on migraine clinical features. Total body obesity had a significant effect on the frequency (OR=4.248), duration (OR=3.167), and intensity (OR=5.225) of the headache.
Total body obesity affected headache frequency, intensity, and duration, while leptin levels did not.
本研究旨在分析肥胖和瘦素水平对偏头痛患者的影响，并观察偏头痛患者瘦素水平的变化。
我们从山东省立医院头痛门诊招募了52例偏头痛患者，进行一项随机对照试验，另选52例年龄、性别和体重指数相匹配的健康受试者作为对照。所有受试者的瘦素水平均采用放射免疫分析法测定。
与对照组相比，偏头痛患者的瘦素水平无显著变化（P>0.05）。多因素Logistic回归分析显示，腹型肥胖和瘦素对偏头痛临床特征均无显著影响。全身肥胖对头痛的频率（OR=4.248）、持续时间（OR=3.167）和强度（OR=5.225）有显著影响。
全身肥胖影响头痛频率、强度和持续时间，而瘦素水平则无此影响。
