Işıktaş Sayılar Emel, Çelik Bülent, Dumlu Şükrü
Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey.
Turk J Gastroenterol. 2015 Nov;26(6):468-73. doi: 10.5152/tjg.2015.0197. Epub 2015 Oct 26.
BACKGROUND/AIMS: To investigate the prevalence of metabolic syndrome (MS) and its components in patients with Helicobacter pylori that was detected using histopathological diagnostic methods.
The study included 200 patients who presented with dyspeptic complaints and had indication for endoscopy. H. pylori-positive [HP (+)] and H. pylori-negative [HP (-)] patients were compared in terms of MS and its components.
The prevalence of H. pylori in general patient population is 49.5%. When patients were examined using a diagnostic criteria of MS, MS was present in 78 patients (78.8%) in the HP (+) (n=99) group and in 22 patients (21.8%) in the HP (-) (n=101) group (p<0.01). Logistic regression analysis revealed that H. pylori infection enhances the risk of developing MS by approximately 3.6 times (Relative Risk - (RR)=3.617, 95% CI: 2.465-5.307, p<0.001). With regard to the MS criteria, mean systolic-diastolic blood pressures and body mass index were significantly higher in HP (+) individuals than in HP (-) individuals. Furthermore, fasting plasma glucose, insulin and homeostatic model assessment-insulin resistance, very low-density lipoproteins, and triglyceride levels were also higher in the HP (+) group, whereas high-density lipoproteins levels were lower.
H. pylori infection is a risk factor for MS. H. pylori leads to insulin resistance by developing chronic inflammation and accordingly facilitates the development of MS.
背景/目的：采用组织病理学诊断方法，调查幽门螺杆菌感染患者中代谢综合征（MS）及其组分的患病率。
本研究纳入200例有消化不良症状且有内镜检查指征的患者。比较幽门螺杆菌阳性[HP(+)]和幽门螺杆菌阴性[HP(-)]患者的MS及其组分情况。
普通患者人群中幽门螺杆菌的患病率为49.5%。按照MS诊断标准对患者进行检查时，HP(+)(n = 99)组中有78例患者（78.8%）存在MS，HP(-)(n = 101)组中有22例患者（21.8%）存在MS（p<0.01）。逻辑回归分析显示，幽门螺杆菌感染使发生MS的风险增加约3.6倍（相对风险 - (RR)=3.617，95%可信区间：2.465 - 5.307，p<0.001）。就MS标准而言，HP(+)个体的平均收缩压 - 舒张压及体重指数显著高于HP(-)个体。此外，HP(+)组的空腹血糖、胰岛素及稳态模型评估 - 胰岛素抵抗、极低密度脂蛋白和甘油三酯水平也较高，而高密度脂蛋白水平较低。
幽门螺杆菌感染是MS的一个危险因素。幽门螺杆菌通过引发慢性炎症导致胰岛素抵抗，从而促进MS的发生。
