Yang Wen, Xuan Cunfu
Geriatric Digestive System Department, Navy General Hospital, No. 6 Fuchenglu Road, Beijing 100048, China.
Department of Cardiology, Shuozhou People's Hospital, No. 263 ShanYang Street, Shuocheng District, Shuozhou, Shanxi 036002, China.
Gastroenterol Res Pract. 2016;2016:6951264. doi: 10.1155/2016/6951264. Epub 2016 Jun 27.
Background. H. pylori infection is one of the most common chronic infectious inflammatory diseases worldwide and is also a risk factor for atherosclerosis. Patients with metabolic syndrome are known to be at increased risk for atherosclerosis. The aim of our study was to assess the effects of H. pylori infection on serum lipids, body mass index (BMI), and metabolic syndrome in old Chinese people. Material and Method. A total of 191 (133 males and 58 females, aged 73.19 ± 11.03 years) people who had gastroscopy examination in our hospital were divided into H. pylori-positive group (n = 80) and H. pylori-negative group (n = 111). H. pylori infection was diagnosed by rapid urease test. Results. Patients with H. pylori infection had higher BMI and fasting glucose levels and incidence of metabolic syndrome (p < 0.01). It was found that BMI (p < 0.01, OR 74.469), H. pylori infection (p < 0.01, OR 5.427), total cholesterol (p < 0.01, OR 15.544), and diabetes mellitus (p < 0.01, OR 23.957) were significantly associated with the risk of metabolic syndrome by binary logistic regression analysis. Conclusions. Patients with H. pylori infection had higher BMI and fasting glucose levels and had incidence of metabolic syndrome.
背景。幽门螺杆菌感染是全球最常见的慢性感染性炎症疾病之一，也是动脉粥样硬化的一个危险因素。已知代谢综合征患者患动脉粥样硬化的风险增加。我们研究的目的是评估幽门螺杆菌感染对中国老年人血清脂质、体重指数（BMI）和代谢综合征的影响。材料与方法。在我院接受胃镜检查的191人（133名男性和58名女性，年龄73.19±11.03岁）被分为幽门螺杆菌阳性组（n = 80）和幽门螺杆菌阴性组（n = 111）。通过快速尿素酶试验诊断幽门螺杆菌感染。结果。幽门螺杆菌感染患者的BMI、空腹血糖水平和代谢综合征发病率更高（p < 0.01）。通过二元逻辑回归分析发现，BMI（p < 0.01，OR 74.469）、幽门螺杆菌感染（p < 0.01，OR 5.427）、总胆固醇（p < 0.01，OR 15.544）和糖尿病（p < 0.01，OR 23.957）与代谢综合征风险显著相关。结论。幽门螺杆菌感染患者的BMI和空腹血糖水平更高，且患有代谢综合征。
