Temesgen Gelagey Baye, Menon Menakath, Gizaw Solomon Tebeje, Yimenu Bayu Wondimneh, Agidew Melaku Mekonen
Department of Biomedical Sciences, Debre Markos University, Debre Markos, Ethiopia.
Department of Medical Biochemistry School of Medicine, College of Health Sciences Addis Ababa University, Addis Ababa, Ethiopia.
Int J Gen Med. 2022 Jan 6;15:271-278. doi: 10.2147/IJGM.S345649. eCollection 2022.
are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and inflammatory marker between positive and negative patients.
To evaluate and compare lipid profile (TC; TG; LDL; HDL) and inflammatory marker (hs-CRP) in dyspeptic patients with and without infection.
Comparative cross-sectional study was conducted from September 2020 to January 2021 at Debre Markos Referral Hospital, Debre Markos Health Center, and Hidassie Health Center, Ethiopia. Each of 50 -positive and negative dyspeptic patients were studied. The data were checked for completeness and analyzed by SPSS version 25.0 Software. A p-value < 0.05 was considered statistically significant.
Serum mean high-density lipoprotein (HDL) values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL (p < 0.05) for -positive and negative dyspeptic patients, respectively, and median serum high sensitive C reactive protein (hs-CRP) levels were 6.29 mg/L (1.66-41.34) and 3.35 mg/L (0.39-10.01) (p < 0.05) for -positive and negative dyspeptic patients, respectively.
infection significantly alters serum high-density lipoprotein (HDL) and high sensitive C reactive protein (hs-CRP) levels in dyspeptic patients, as a result, increase the potential risk of cardiovascular diseases.
是革兰氏阴性、微需氧的螺旋形细菌，有多个鞭毛，通常存在于胃中。这种感染可能导致严重的黏膜炎症和损伤，进而引发胃溃疡。它还会影响胃肠道以外的器官系统。为了评估心血管危险因素并预测心血管疾病，我们正在评估和比较阳性和阴性患者的血脂谱和炎症标志物。
评估和比较有和没有感染的消化不良患者的血脂谱（总胆固醇；甘油三酯；低密度脂蛋白；高密度脂蛋白）和炎症标志物（高敏C反应蛋白）。
2020年9月至2021年1月在埃塞俄比亚德布雷马科斯转诊医院、德布雷马科斯健康中心和希达西健康中心进行了比较横断面研究。对50名阳性和阴性消化不良患者分别进行了研究。检查数据的完整性，并使用SPSS 25.0软件进行分析。p值<0.05被认为具有统计学意义。
阳性和阴性消化不良患者的血清平均高密度脂蛋白（HDL）值分别为37.54±7.98mg/dL和43.12±7.86mg/dL（p<0.05），阳性和阴性消化不良患者的血清高敏C反应蛋白（hs-CRP）水平中位数分别为6.29mg/L（1.66 - 41.34）和3.35mg/L（0.39 - 10.01）（p<0.05）。
感染显著改变了消化不良患者的血清高密度脂蛋白（HDL）和高敏C反应蛋白（hs-CRP）水平，从而增加了心血管疾病的潜在风险。
