Lauritano D, Cura F, Candotto V, Gaudio R M, Mucchi D, Carinci F
Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy.
Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.
J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3 Suppl 1):127-30.
The use of chemical devices for non-surgical periodontal therapy has led to new treatment strategies aimed primarily at controlling infection. Over the last few years, titanium dioxide (TiO2) with monovalent silver ions (A) covalently linked and added to benzalkonium (B) (named TIAB) has been subjected to medical studies, especially in dermatology. The purpose of the present study was to assess the effect of TIAB on the red complex bacteria using Polymerase Chain Reaction (PCR) for microbiological analysis. A split mouth study was conducted, and 10 subjects were enrolled. TIAB as topical medication was placed at study sites after scaling and root planing. Sub-gingival plaque samples were collected after 2 weeks, and red complex micro-organisms were studied using PCR. SPSS program was used for statistical purposes and a paired sample correlation was performed at the end of the observation period between treated and untreated sites. The results showed statistically significant reduction of red complex organisms in the study compared to the control group. TIAB can be used as an effective local drug along with supportive periodontal therapy in treatment of chronic periodontitis.
用于非手术牙周治疗的化学装置已带来了主要旨在控制感染的新治疗策略。在过去几年中，共价连接有一价银离子（A）并添加到苯扎氯铵（B）中的二氧化钛（TiO₂）（命名为TIAB）已接受医学研究，尤其是在皮肤病学领域。本研究的目的是使用聚合酶链反应（PCR）进行微生物分析，以评估TIAB对红色复合体细菌的影响。进行了一项双侧对照研究，招募了10名受试者。在刮治和根面平整后，将TIAB作为局部用药放置在研究部位。2周后收集龈下菌斑样本，并使用PCR研究红色复合体微生物。使用SPSS程序进行统计分析，并在观察期结束时对治疗部位和未治疗部位进行配对样本相关性分析。结果显示，与对照组相比，研究中红色复合体微生物数量有统计学意义的减少。TIAB可作为一种有效的局部药物，与支持性牙周治疗一起用于治疗慢性牙周炎。
