纳米拓扑结构在药物递送中的应用。
Nanotopography applications in drug delivery.
作者信息
Walsh Laura A, Allen Jessica L, Desai Tejal A
机构信息
a UC Berkeley & UCSF Graduate Program in Bioengineering, UCSF Mission Bay Campus , San Francisco , CA 94158 , USA.
b Department of Bioengineering and Therapeutic Sciences , University of California , San Francisco , CA 94158 , USA.
出版信息
Expert Opin Drug Deliv. 2015;12(12):1823-7. doi: 10.1517/17425247.2015.1103734. Epub 2015 Oct 29.
Refinement of micro- and nanofabrication in the semiconductor field has led to innovations in biomedical technologies. Nanotopography, in particular, shows great potential in facilitating drug delivery. The flexibility of fabrication techniques has created a diverse array of topographies that have been developed for drug delivery applications. Nanowires and nanostraws deliver drug cytosolically for in vitro and ex vivo applications. In vivo drug delivery is limited by the barrier function of the epithelium. Nanowires on microspheres increase adhesion and residence time for oral drug delivery, while also increasing permeability of the epithelium. Low aspect ratio nanocolumns increase paracellular permeability, and in conjunction with microneedles increase transdermal drug delivery of biologics in vivo. In summary, nanotopography is a versatile tool for drug delivery. It can deliver directly to cells or be used for in vivo delivery across epithelial barriers. This editorial highlights the application of nanotopography in the field of drug delivery.
半导体领域微纳制造技术的改进推动了生物医学技术的创新。特别是纳米拓扑结构在促进药物递送方面显示出巨大潜力。制造技术的灵活性创造了各种各样为药物递送应用而开发的拓扑结构。纳米线和纳米吸管可将药物递送至细胞溶质，用于体外和离体应用。体内药物递送受到上皮屏障功能的限制。微球上的纳米线可增加口服药物递送的粘附力和滞留时间，同时还能增加上皮的通透性。低纵横比的纳米柱可增加细胞旁通透性，并与微针结合可增加体内生物制剂的透皮药物递送。总之，纳米拓扑结构是一种用于药物递送的通用工具。它可以直接递送至细胞，或用于跨越上皮屏障的体内递送。这篇社论重点介绍了纳米拓扑结构在药物递送领域的应用。
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