D'Ignazio Laura, Bandarra Daniel, Rocha Sonia
Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, UK.
FEBS J. 2016 Feb;283(3):413-24. doi: 10.1111/febs.13578. Epub 2015 Nov 24.
Hypoxia and inflammation have been associated with a number of pathological conditions, in particular inflammatory diseases. While hypoxia is mainly associated with the activation of hypoxia-inducible factors (HIFs), inflammation activates the family of transcription factor called nuclear factor-kappa B (NF-κB). An extensive crosstalk between these two main molecular players involved in hypoxia and inflammation has been demonstrated. This crosstalk includes common activating stimuli, shared regulators and targets. In this review, we discuss the current understanding of the role of NF-κB and HIF in the context of the immune response. We review the crosstalk between HIF and NF-κB in the control of the immune response in different immune cell types including macrophages, neutrophils and B and T cells. Furthermore the importance of the molecular crosstalk between HIFs and NF-κB for a variety of medical conditions will be discussed.
缺氧和炎症与许多病理状况相关，尤其是炎症性疾病。虽然缺氧主要与缺氧诱导因子（HIFs）的激活有关，但炎症会激活名为核因子-κB（NF-κB）的转录因子家族。已经证明参与缺氧和炎症的这两个主要分子参与者之间存在广泛的相互作用。这种相互作用包括共同的激活刺激、共享的调节因子和靶点。在这篇综述中，我们讨论了目前对NF-κB和HIF在免疫反应中的作用的理解。我们回顾了HIF和NF-κB在不同免疫细胞类型（包括巨噬细胞、中性粒细胞以及B细胞和T细胞）的免疫反应控制中的相互作用。此外，还将讨论HIFs和NF-κB之间的分子相互作用对多种医学状况的重要性。
