[白细胞介素-17和白细胞介素-23在变应性鼻炎和非变应性鼻炎患者血清及鼻分泌物中的表达水平及意义]
[Expression level and significance of IL-17 and IL-23 in serum and nasal secretion of patients with allergic rhinitis and non-allergrie rhinitis].
作者信息
Yang Guang, Zheng Guoxi, Zhang Luyao, Zhu Kang, Xin Wenjun, Wei Junrong
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1086-90.
OBJECTIVE
To investigate the effect of IL-17 and IL-23 in the pathogenesis of allergic rhinitis(AR) and non. allergic rhinitis(NAR).
METHOD
Selected 156 cases of patients with allergic rhinitis (AR group) and 59 cases of patients with non-allergic rhinitis (NAR group), 60 cases of healthy people (control group). All cases in AR group and NAR groups were evaluated by a visual analog scale (VAS) score of nasal symptoms. Collected peripheral blood and nasal secretions in all cases and then detected IL-17 and IL-23 expression levels.
RESULT
There was no significant difference in VAS score of AR group and NAR group (P>0. 05). IL-17 and IL-23 levels of serum and nasal secretions in AR group and NAR group were both higher than control group, with a highly significant difference (P <0. 05). The research showed a clear correlation between expression of IL-17 and IL-23 both in serum and nasal secretions of AR group and NAR(P<0. 05).
CONCLUSION
IL-17 and IL-23 may be important cytokines and IL-23/IL-17 pathway may play a significant role in the pathogenesis of allergic rhinitis and non-allergic rhinitis.
目的
探讨白细胞介素-17（IL-17）和白细胞介素-23（IL-23）在变应性鼻炎（AR）和非变应性鼻炎（NAR）发病机制中的作用。
方法
选取156例变应性鼻炎患者（AR组）、59例非变应性鼻炎患者（NAR组）及60例健康人（对照组）。采用视觉模拟评分法（VAS）对AR组和NAR组所有患者的鼻部症状进行评分。采集所有研究对象的外周血和鼻分泌物，检测IL-17和IL-23的表达水平。
结果
AR组和NAR组的VAS评分差异无统计学意义（P>0.05）。AR组和NAR组血清及鼻分泌物中IL-17和IL-23水平均高于对照组，差异有高度统计学意义（P<0.05）。研究表明，AR组和NAR组血清及鼻分泌物中IL-17和IL-23的表达呈明显相关性（P<0.05）。
结论
IL-17和IL-23可能是重要的细胞因子，IL-23/IL-17信号通路可能在变应性鼻炎和非变应性鼻炎的发病机制中起重要作用。
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