Farah Breno Q, Ritti-Dias Raphael M, Montgomery Polly S, Casanegra Ana I, Silva-Palacios Federico, Gardner Andrew W
Graduate Program in Physical Education, University of Pernambuco, Recife, Brazil.
Graduate Program in Physical Education, University of Pernambuco, Recife, Brazil; Albert Einstein Hospital, São Paulo, Brazil.
J Vasc Surg. 2016 Mar;63(3):657-63. doi: 10.1016/j.jvs.2015.09.018. Epub 2015 Oct 27.
Time spent in sedentary behavior has been associated with worse inflammation and cardiometabolic biomarkers in various populations. However, the association between time spent in sedentary behavior and biomarkers remains unknown in patients with intermittent claudication. The aim of the current study was to analyze the relationship between sedentary behavior and inflammatory and cardiometabolic biomarkers in patients with symptomatic peripheral arterial disease (PAD).
The sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained.
Time spent in sedentary behavior was related with high-sensitivity C-reactive protein (b = 0.187; P = .005), glucose (b = 0.238; P < .001), fibrinogen (b = 0.167; P = .017), plasminogen activator inhibitor 1 activity (b = 0.143; P = .036), and high-density lipoprotein cholesterol (b = -0.133; P = .029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (b = 0.170; P = .015), glucose (b = 0.178; P = .004), fibrinogen (b = 0.189; P = .010), and high-density lipoprotein cholesterol (b = -0.128; P = .032).
Time spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.
在不同人群中，久坐行为时间与更差的炎症反应及心血管代谢生物标志物相关。然而，间歇性跛行患者的久坐行为时间与生物标志物之间的关联尚不清楚。本研究的目的是分析有症状外周动脉疾病（PAD）患者的久坐行为与炎症及心血管代谢生物标志物之间的关系。
样本包括297例间歇性跛行患者。使用步数活动监测器评估久坐行为。评估炎症、氧化应激、血脂谱、胰岛素抵抗和内源性纤维蛋白溶解的生物标志物。还获取了人口统计学数据、体重指数、身体活动状况以及PAD严重程度的测量值（踝臂指数、峰值步行时间和缺血窗口）。
久坐行为时间与高敏C反应蛋白（b = 0.187；P = 0.005）、血糖（b = 0.238；P < 0.001）、纤维蛋白原（b = 0.167；P = 0.017）、纤溶酶原激活物抑制剂1活性（b = 0.143；P = 0.036）和高密度脂蛋白胆固醇（b = -0.133；P = 0.029）相关。在对性别、年龄、身体活动状况、体重指数和PAD严重程度进行校正后，久坐行为仍与高敏C反应蛋白（b = 0.170；P = 0.015）、血糖（b = 0.178；P = 0.004）、纤维蛋白原（b = 0.189；P = 0.010）和高密度脂蛋白胆固醇（b = -0.128；P = 0.032）相关。
间歇性跛行患者的久坐活动时间与更差的炎症及心血管代谢状况相关。
