Mood Disorders Center, Beijing Anding Hospital, Capital Medical University, Beijing, China & China Clinical Research Center for Mental Disorders, China; Center of Depression, Beijing Institute for Brain Disorders, Beijing, China & Department of Psychiatry, Capital Medical University, Beijing, China.
Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Avenida da Universidade, 3/F, Building E12, Taipa, Macao SAR, China.
J Affect Disord. 2016 Jan 15;190:214-220. doi: 10.1016/j.jad.2015.09.057. Epub 2015 Oct 24.
Bipolar disorder (BD) is often misdiagnosed as major depressive disorder (MDD). This study tested the psychometric properties and the accuracy of the Chinese version of the 33-item Hypomania Checklist (HCL-33) to identify BD in Chinese clinical settings.
A total of 350 depressed patients were consecutively interviewed in a major psychiatric hospital in China. The patients' socio-demographic and clinical characteristics were recorded using standardized protocol and data collection procedures. The HCL-33 was completed by patients to detect symptoms characteristic of mania and hypomania. DSM-IV diagnoses were established using the Mini International Neuropsychiatric Interview (MINI).
The HCL-33 showed high internal consistency with two-factorial dimensions. The optimal cut-off point on the HCL-33 to differentiate BD from MDD was 15, while cut-off points of 14 and 13 differentiated BD-I and BD-II from MDD, respectively. The maximum sensitivity was 0.62, 0.67 and 0.72 for differentiating BD, BD-I and BD-II from MDD, respectively.
The HCL-33 is a useful tool for screening for BD in Chinese depressed patients. The routine clinical use of the HCL-33 as a screening instrument for BD in Chinese patients is recommended.
双相情感障碍（BD）常被误诊为单相重性抑郁障碍（MDD）。本研究测试了 33 项轻躁狂清单（HCL-33）中文版的心理测量特性和准确性，以识别中国临床环境中的 BD。
在中国的一家主要精神病院连续对 350 名抑郁患者进行访谈。使用标准化方案和数据收集程序记录患者的社会人口统计学和临床特征。患者完成 HCL-33 以检测躁狂和轻躁狂的特征症状。使用迷你国际神经精神访谈（MINI）确定 DSM-IV 诊断。
HCL-33 具有两个因子维度的高内部一致性。区分 BD 和 MDD 的最佳 HCL-33 截断值为 15，而 14 和 13 的截断值分别区分 BD-I 和 BD-II 与 MDD。区分 BD、BD-I 和 BD-II 与 MDD 的最大敏感性分别为 0.62、0.67 和 0.72。
HCL-33 是筛查中国抑郁患者 BD 的有用工具。建议常规临床使用 HCL-33 作为中国患者 BD 的筛查工具。
