Horcajada-Reales C, Pulido-Pérez A, Suárez-Fernández R
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España.
Actas Dermosifiliogr. 2016 Jan-Feb;107(1):23-33. doi: 10.1016/j.ad.2015.08.006. Epub 2015 Nov 11.
Acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms are all severe hypersensitivity reactions to medications. While each of these reactions is a well-established entity with specific diagnostic criteria, clinicians see cases that fulfill criteria for more than one form, prompting discussion on the possibility of combined forms. Such overlapping clinical pictures meeting the criteria for 2 conditions have thus become a topic of debate in dermatology in recent years. We describe 2 patients with cutaneous drug reactions having the characteristics of both acute generalized exanthematous pustulosis and Stevens-Johnson syndrome -toxic epidermal necrolysis. We also review previously published cases and current thinking on such overlapping conditions.
急性泛发性脓疱性皮病、史蒂文斯-约翰逊综合征、中毒性表皮坏死松解症以及伴有嗜酸性粒细胞增多和全身症状的药物反应均为对药物的严重超敏反应。虽然这些反应中的每一种都是具有特定诊断标准的既定实体，但临床医生会遇到符合不止一种形式标准的病例，这引发了关于合并形式可能性的讨论。因此，近年来，符合两种疾病标准的这种重叠临床症状已成为皮肤科领域的一个争论话题。我们描述了2例具有急性泛发性脓疱性皮病和史蒂文斯-约翰逊综合征-中毒性表皮坏死松解症特征的皮肤药物反应患者。我们还回顾了先前发表的病例以及关于此类重叠病症的当前观点。
