Awan Kamran Habib, Patil Shankargouda
Assistant Professor, Department of Oral Medicine and Diagnostic Sciences College of Dentistry, King Saud University, Riyadh, Saudi Arabia, Phone: (966) (1) 467-7422, e-mail:
Department of Oral Pathology, Faculty of Dental Sciences MS Ramaiah University of Applied Sciences, Bengaluru Karnataka, India.
J Contemp Dent Pract. 2015 Sep 1;16(9):744-9. doi: 10.5005/jp-journals-10024-1751.
Oral cancer is a serious global issue and early diagnosis of oral cancer is the key in reducing the high mortality rate. Autofluorescence properties of oral mucosa have been gaining interest in the field of early diagnosis of oral premalignant lesions.
The aim of the study was to evaluate the clinical usefulness of an autofluorescence based imaging system to detect oral premalignant and malignant lesions.
A systematic review of the English-language literature to evaluate the effectiveness of visually enhanced lesion scope (VELscope) published between 1966 and March, 2014 was undertaken. Data relating to study design, sampling and characteristics of the study group, interventions, and reported outcomes and diagnostic value of VELscope were abstracted from articles meeting inclusion and exclusion criteria.
Eleven articles that met the inclusion criteria were included. In nine studies, all the lesions underwent histological assessment, whereas the remaining four studies only performed histological assessment on suspicious lesions. Visually enhanced lesion scope showed high sensitivity values in detecting oral premalignant and malignant lesions. However, most of the studies reported it inability in discriminating dysplasia cases from nondysplasia cases.
There is insufficient evidence to support the use of VELscope in primary care setting, however, they may be useful in hands of a specialist.
口腔癌是一个严重的全球性问题，早期诊断是降低口腔癌高死亡率的关键。口腔黏膜的自体荧光特性在口腔癌前病变的早期诊断领域越来越受到关注。
本研究旨在评估基于自体荧光的成像系统检测口腔癌前病变和恶性病变的临床实用性。
对1966年至2014年3月间发表的评估视觉增强病变范围（VELscope）有效性的英文文献进行系统综述。从符合纳入和排除标准的文章中提取与研究设计、研究组的抽样和特征、干预措施以及VELscope报告的结果和诊断价值相关的数据。
纳入了11篇符合纳入标准的文章。在9项研究中，所有病变均进行了组织学评估，而其余4项研究仅对可疑病变进行了组织学评估。视觉增强病变范围在检测口腔癌前病变和恶性病变方面显示出较高的敏感性值。然而，大多数研究报告其无法区分发育异常病例和非发育异常病例。
没有足够的证据支持在初级保健环境中使用VELscope，然而，在专家手中它们可能会有用。
