BACKGROUND: In recent years, the incidence of oral carcinoma has been increasing year by year, and the role of macrophages in oral carcinoma cannot be ignored. Many related studies have been published, but until now, there is no bibliometric analysis of these publications. METHODS: The global publications about oral carcinoma and macrophages from January 2011 to December 2021 were extracted from Web of Science collection database. Microsoft Excel 2016, GraphPad Prism 8, VOSviewer software and CiteSpace were employed to perform the bibliometric study. RESULTS: China published the most publications in this field and had the most citations as well as H-index. published the most papers relating to the oral carcinoma and macrophages in terms of journals. have most publications in terms of institutions and research by received the highest number of citations. CONCLUSION: The squamous cell carcinoma is still the focus of our attention at present. The polarization of macrophages, immunotherapy and the prevention of oral cancer were identified as the emerging topics. However, the collaboration of immunology and oncology has played an important role in the development of this field.