School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
School of Professional Health Education at the Hospital de Clínicas de Porto Alegre, Brazil; Department of Morphological Sciences, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102764. doi: 10.1016/j.pdpdt.2022.102764. Epub 2022 Feb 19.
Oral potentially malignant disorders (OPMD) represent a group of lesions with increased risk for malignant transformation. The management of such injuries is based on surgical treatment or detailed follow-up throughout the patient's lifetime. This systematic review and meta-analysis investigated and critically evaluated the use of autofluorescence and fluorescent probes as potential techniques for the early detection of OPMD. A comprehensive search was performed on Pubmed, Scopus, Web of Science and LIVIVO databases. The gray literature was also consulted and included Google Scholar, Proquest and Open gray databases. 2715 articles were retrieved, and after the different stages of critical evaluation, were reduced to 25 articles that fully met the inclusion criteria. VELscope® was the most used equipment for autofluorescence, while aminolevulinic acid (5-ALA) was the main representative of the probes. The meta-analysis performed included 10 articles that used VELscope® as a method to detect oral disorders. A 95% confidence interval (CI) with a p value significance <0.05 was considered as a criterion for the statistical analysis. The combined sensitivity was 74% (CI95 60-76%, p = 0.0001) and the specificity was 57% (CI95 52-60%, p = 0.0000). The inclusion of these adjunct methods in clinical practice is very promising, since they are able to help both the clinician and the specialist in the early detection of potentially malignant oral disorders, favoring a better prognosis. However, it is still necessary to carry out further studies, with the aim of establishing a protocol for use and qualification of results.
口腔潜在恶性疾病（OPMD）代表一组具有恶性转化风险增加的病变。这些损伤的管理基于手术治疗或在患者的整个生命周期内进行详细的随访。本系统评价和荟萃分析研究并批判性评估了自发荧光和荧光探针作为早期检测 OPMD 的潜在技术的应用。在 Pubmed、Scopus、Web of Science 和 LIVIVO 数据库中进行了全面搜索。还查阅了灰色文献，并包括 Google Scholar、Proquest 和 Open gray 数据库。检索到 2715 篇文章，经过不同阶段的严格评估，减少到 25 篇完全符合纳入标准的文章。VELscope®是用于自发荧光的最常用设备，而氨基酮戊酸（5-ALA）是探针的主要代表。进行的荟萃分析包括 10 篇使用 VELscope®作为检测口腔疾病的方法的文章。置信区间（CI）为 95%，p 值显著性<0.05 被认为是统计分析的标准。合并敏感性为 74%（CI95 60-76%，p=0.0001），特异性为 57%（CI95 52-60%，p=0.0000）。这些辅助方法纳入临床实践是非常有前途的，因为它们能够帮助临床医生和专家早期发现潜在恶性口腔疾病，从而改善预后。然而，仍有必要进行进一步的研究，旨在建立使用和结果资格的协议。
