一个存在闭塞性细支气管炎哨兵病例的咖啡加工工作场所中的呼吸道发病率。
Respiratory morbidity in a coffee processing workplace with sentinel obliterative bronchiolitis cases.
作者信息
Bailey Rachel L, Cox-Ganser Jean M, Duling Matthew G, LeBouf Ryan F, Martin Stephen B, Bledsoe Toni A, Green Brett J, Kreiss Kathleen
机构信息
Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Respiratory Health Division, Field Studies Branch, Morgantown, WV.
CDC, NIOSH, Health Effects Laboratory Division, Allergy and Clinical Immunology Branch, Morgantown, WV.
出版信息
Am J Ind Med. 2015 Dec;58(12):1235-45. doi: 10.1002/ajim.22533. Epub 2015 Nov 2.
RATIONALE
Obliterative bronchiolitis in former coffee workers prompted a cross-sectional study of current workers. Diacetyl and 2,3-pentanedione levels were highest in areas for flavoring and grinding/packaging unflavored coffee.
METHODS
We interviewed 75 (88%) workers, measured lung function, and created exposure groups based on work history. We calculated standardized morbidity ratios (SMRs) for symptoms and spirometric abnormalities. We examined health outcomes by exposure groups.
RESULTS
SMRs were elevated 1.6-fold for dyspnea and 2.7-fold for obstruction. The exposure group working in both coffee flavoring and grinding/packaging of unflavored coffee areas had significantly lower mean ratio of forced expiratory volume in 1 s to forced vital capacity and percent predicted mid-expiratory flow than workers without such exposure.
CONCLUSION
Current workers have occupational lung morbidity associated with high diacetyl and 2,3-pentanedione exposures, which were not limited to flavoring areas.
原理
former coffee workers中闭塞性细支气管炎促使对现职员工进行了一项横断面研究。二乙酰和2,3 - 戊二酮水平在调味以及研磨/包装无调味咖啡的区域最高。
方法
我们采访了75名（88%）员工，测量了肺功能，并根据工作经历创建了暴露组。我们计算了症状和肺量计异常的标准化发病比（SMR）。我们按暴露组检查了健康结果。
结果
呼吸困难的SMR升高了1.6倍，阻塞的SMR升高了2.7倍。在咖啡调味以及无调味咖啡研磨/包装两个区域工作的暴露组，其1秒用力呼气量与用力肺活量的平均比值以及预计呼气中期流速百分比显著低于无此类暴露的员工。
结论
现职员工存在与高浓度二乙酰和2,3 - 戊二酮暴露相关的职业性肺病，且这种暴露并不局限于调味区域。
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