Nf1失活揭示成年海马神经干细胞的潜在三系分化潜能
Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation.
作者信息
Sun Gerald J, Zhou Yi, Ito Shiori, Bonaguidi Michael A, Stein-O'Brien Genevieve, Kawasaki Nicholas K, Modak Nikhil, Zhu Yuan, Ming Guo-li, Song Hongjun
机构信息
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Nat Neurosci. 2015 Dec;18(12):1722-4. doi: 10.1038/nn.4159. Epub 2015 Nov 2.
Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.
成年海马体中的内源性神经干细胞（NSCs）被认为是双能的，因为它们在体内仅产生神经元和星形胶质细胞。在小鼠中，我们发现神经纤维瘤蛋白1（Nf1）（一种在1型神经纤维瘤病中发生突变的基因）的失活开启了一种潜在的少突胶质细胞谱系潜能，使其能够在体内从神经干细胞产生所有三种谱系。我们的研究结果为通过靶向潜在谱系潜能的障碍来促进干细胞可塑性提供了一条途径。
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