Dewinter Louise, Casteels Kristina, Corthouts Karen, Van de Kerckhove Kristel, Van der Vaerent Katrien, Vanmeerbeeck Kelly, Matthys Christophe
a Department of Health and Technology , University College Leuven , Leuven , Belgium.
b Department of Pediatrics , University Hospitals Leuven , Leuven , Belgium.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33(1):19-26. doi: 10.1080/19440049.2015.1112039. Epub 2015 Nov 16.
The aims of the current cross-sectional study were (1) to assess the intake of aspartame, cyclamate, acesulfame-k, neohesperidine dihydrochalcone, sucralose, saccharin, steviol glycosides and neotame among children with type 1 diabetes mellitus (T1D); (2) to compare the obtained intakes with the respective acceptable daily intake (ADI) values; and (3) to conduct a scenario analysis to obtain practical guidelines for a safe consumption of non-nutritive sweeteners (NNS) among children with T1D. T1D patients of the Paediatrics Department of the University Hospitals Leuven were invited to complete a food frequency questionnaire designed to assess NNS intake using a tier 2 and tier 3 exposure assessment approach. A scenario analysis was conducted by reducing the P95 consumption of the most contributing food categories in order to reach a total sweetener intake lower than or equal to the ADI. Estimated total intakes higher than ADIs were only found for the P95 consumers only of acesulfame-k, cyclamate and steviol glycosides (tier 2 and tier 3 approach). Scenario analysis created dietary guidelines for each age category for diet soda, bread spreads and dairy drinks. There is little chance for T1D children to exceed the ADI of the different NNS, however diabetes educators and dieticians need to pay attention regarding the use of NNS.
（1）评估1型糖尿病（T1D）患儿阿斯巴甜、甜蜜素、安赛蜜、新橙皮苷二氢查耳酮、三氯蔗糖、糖精、甜菊糖苷和纽甜的摄入量；（2）将所获得的摄入量与各自的每日可接受摄入量（ADI）值进行比较；（3）进行情景分析，以获取T1D患儿安全食用非营养性甜味剂（NNS）的实用指南。鲁汶大学医院儿科的T1D患者受邀填写一份食物频率问卷，该问卷旨在使用二级和三级暴露评估方法评估NNS摄入量。通过降低对总摄入量贡献最大的食物类别的第95百分位数消费量来进行情景分析，以使甜味剂总摄入量低于或等于ADI。仅在第95百分位数的安赛蜜、甜蜜素和甜菊糖苷消费者中发现估计总摄入量高于ADI（二级和三级方法）。情景分析为各年龄组的无糖汽水、面包涂抹酱和乳饮料制定了饮食指南。T1D患儿几乎没有机会超过不同NNS的ADI，然而糖尿病教育工作者和营养师在NNS的使用方面需要予以关注。
