Xu Wen-Ning, Jiang Zu-Jun, Li Yong-Hua, Xiao Hao-Wen, Gao Yang, Pang Yan, Ouyang Lin, Liu Zeng-Hui, Zhang Le-Qing, Wang Yang, Xiao Yang
Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.
Department of Hematology, The First People Hospital of Foshan Municipality, Guangdong Province, Foshan 528000, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Oct;23(5):1258-64. doi: 10.7534/j.issn.1009-2137.2015.05.007.
To explore the correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia (AL) (except M3) after first chemotherapy in Chinese Han population.
Blood samples obtained from 76 fever patients with AL during neutropenia episodes were detected to analyse single nucleotide polymorphism (SNP) in the MBL ExonI 54 and NFκB1-94ins/del ATTG gene, and analyse the correlation between above-mentioned 2 polymorphisms and fever during neutropenia of AL patients after chemotherapy.
In 76 patients, no correlation were found between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy (P > 0.05). No significant relation were found in sex, age, underlying disease, disease status or degrees of neutropenia in febrile neutropenia between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism (P > 0.05). However, patients with MBL ExonI 54 mutation presented longer febrile duration with a median of 5 days compared to 3 days of patients with wildtype MBL ExonI 54 genotype (P < 0.05).
There is no clear correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy. However, the patients with MBL ExonI 54 mutation have been observed to present a longer febrile duration.
探讨中国汉族人群急性白血病（AL，M3除外）患者首次化疗后中性粒细胞减少期MBL外显子I 54和NFκB1 - 94ins/del ATTG基因多态性与发热的相关性。
采集76例急性白血病患者中性粒细胞减少期发热时的血样，检测MBL外显子I 54和NFκB1 - 94ins/del ATTG基因的单核苷酸多态性（SNP），分析上述两种多态性与化疗后急性白血病患者中性粒细胞减少期发热的相关性。
76例患者中，化疗后急性白血病患者中性粒细胞减少期MBL外显子I 54和NFκB1 - 94ins/del ATTG基因多态性与发热无相关性（P>0.05）。MBL外显子I 54和NFκB1 - 94ins/del ATTG基因多态性在发热性中性粒细胞减少患者的性别、年龄、基础疾病、疾病状态或中性粒细胞减少程度方面无显著相关性（P>0.05）。然而，与MBL外显子I 54野生型基因型患者的3天相比，MBL外显子I 54突变患者的发热持续时间更长，中位数为5天（P<0.05）。
化疗后急性白血病患者中性粒细胞减少期MBL外显子I 54和NFκB1 - 94ins/del ATTG基因多态性与发热无明显相关性。然而，观察到MBL外显子I 54突变患者的发热持续时间更长。
