Zhang Rongmin, Sun Bin, Wang Yang, Lei Lei, Schwarz Stefan, Wu Congming
Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Animal Science and Veterinary Medicine College of Heilongjiang Bayi Agriculture University, Daqing, Heilongjiang, People's Republic of China.
Antimicrob Agents Chemother. 2015 Nov 2;60(1):658-61. doi: 10.1128/AAC.02114-15. Print 2016 Jan.
The multiresistance gene cfr was found in two porcine Escherichia coli isolates, one harboring it on the conjugative 33,885-bp plasmid pFSEC-01, the other harboring it in the chromosomal DNA. Sequence analysis of pFSEC-01 revealed that a 6,769-bp fragment containing the cfr gene bracketed by two IS26 elements was inserted into a plasmid closely related to pEA3 from the plant pathogen Erwinia amylovora, suggesting that pFSEC-01 may be transferred between different bacterial genera of both animal and plant origin.
在两株猪源大肠杆菌分离株中发现了多重耐药基因cfr,一株在大小为33,885 bp的接合性质粒pFSEC - 01上携带该基因,另一株在染色体DNA中携带该基因。对pFSEC - 01的序列分析表明,一个含有cfr基因且两侧被两个IS26元件包围的6,769 bp片段插入到了一个与植物病原菌梨火疫欧文氏菌的pEA3密切相关的质粒中,这表明pFSEC - 01可能在动物和植物来源的不同细菌属之间转移。