来自动物的细菌作为抗菌药物耐药基因库。
Bacteria from Animals as a Pool of Antimicrobial Resistance Genes.
作者信息
Argudín Maria Angeles, Deplano Ariane, Meghraoui Alaeddine, Dodémont Magali, Heinrichs Amelie, Denis Olivier, Nonhoff Claire, Roisin Sandrine
机构信息
National Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium.
Ecole de Santé Publique, Université Libre de Bruxelles, Avenue Franklin Roosevelt 50, 1050 Bruxelles, Belgium.
出版信息
Antibiotics (Basel). 2017 Jun 6;6(2):12. doi: 10.3390/antibiotics6020012.
Antimicrobial agents are used in both veterinary and human medicine. The intensive use of antimicrobials in animals may promote the fixation of antimicrobial resistance genes in bacteria, which may be zoonotic or capable to transfer these genes to human-adapted pathogens or to human gut microbiota via direct contact, food or the environment. This review summarizes the current knowledge of the use of antimicrobial agents in animal health and explores the role of bacteria from animals as a pool of antimicrobial resistance genes for human bacteria. This review focused in relevant examples within the ESC(K)APE (, , (), , , and ) group of bacterial pathogens that are the leading cause of nosocomial infections throughout the world.
抗菌剂在兽医学和人类医学中均有应用。在动物中大量使用抗菌剂可能会促使细菌中抗菌抗性基因固定下来，这些基因可能是人畜共患病原体，或者能够通过直接接触、食物或环境将这些基因转移至适应人类的病原体或人类肠道微生物群。本综述总结了目前关于抗菌剂在动物健康领域应用的知识，并探讨了动物源细菌作为人类细菌抗菌抗性基因库的作用。本综述聚焦于ESC(K)APE（肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌科细菌）组细菌病原体中的相关实例，这些病原体是全球医院感染的主要原因。
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