Park Young Gun, Kang Seungbum, Brinkmann Ralf, Roh Young-Jung
Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, No. 10, 63-ro Yeongdeungpo-gu, Seoul 07345, Republic of Korea.
Medical Laser Center Lübeck GmbH, Lübeck, Germany.
J Ophthalmol. 2015;2015:247259. doi: 10.1155/2015/247259. Epub 2015 Oct 7.
Purpose. This study evaluates functional changes in electroretinographic findings after selective retina therapy (SRT) compared to panretinal photocoagulation (PRP) in rabbits. Methods. The right eyes of 12 Chinchilla rabbits received 200 laser treatment spots. The right eyes of six rabbits received SRT (SRT group), whereas the other six animals were treated using PRP on the right eye (PRP group). The eyes were investigated using full-field ERG 1 hour and 3 weeks after treatment. Histologic exam to assess the tissue response of lasers was performed on 3 weeks. Results. No significant changes in the mean ROD or CR b-wave amplitudes of the SRT lesions were evident, compared to baseline, 1 h after laser treatment (p = 0.372 and 0.278, resp.). In addition, the OPs and 30 Hz flickers of the SRT lesions were not significantly altered (p = 0.17 and 0.243, resp.). At 3 weeks, similar results were found. Comparing the two groups, the ROD b-wave amplitude was reduced in the PRP and SRT groups to 60.04 ± 4.2% and 92.32 ± 6.43% of baseline (p < 0.001). Histologically, there was no visible photoreceptor alterations on week 3. Conclusions. SRT in rabbit eyes induced less functional loss than PRP in both rod-mediated retinal function and cone-mediated retinal function. In addition, SRT irradiated eyes had no functional loss compared to its control.
目的。本研究评估与兔全视网膜光凝术（PRP）相比，选择性视网膜治疗（SRT）后视网膜电图检查结果的功能变化。方法。12只青紫蓝兔的右眼接受200个激光治疗点。6只兔的右眼接受SRT（SRT组），而另外6只动物的右眼接受PRP治疗（PRP组）。在治疗后1小时和3周使用全视野视网膜电图对眼睛进行检查。在3周时进行组织学检查以评估激光的组织反应。结果。与激光治疗后1小时的基线相比，SRT损伤的平均视杆（ROD）或视锥（CR）b波振幅无明显变化（分别为p = 0.372和0.278）。此外，SRT损伤的振荡电位（OPs）和30Hz闪烁也无明显改变（分别为p = 0.17和0.243）。在3周时，发现了类似的结果。比较两组，PRP组和SRT组的ROD b波振幅分别降至基线的60.04±4.2%和92.32±6.43%（p < 0.001）。组织学上，第3周时未见明显的光感受器改变。结论。兔眼的SRT在视杆介导的视网膜功能和视锥介导的视网膜功能方面比PRP引起的功能损失更少。此外，与对照相比，接受SRT照射的眼睛没有功能损失。
