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“某些物质”的博弈：蛋白质破坏与结核分枝杆菌致病机制

Game of 'Somes: Protein Destruction for Mycobacterium tuberculosis Pathogenesis.

作者信息

Samanovic Marie I, Darwin K Heran

机构信息

New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236 New York, NY 10016, USA.

New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236 New York, NY 10016, USA.

出版信息

Trends Microbiol. 2016 Jan;24(1):26-34. doi: 10.1016/j.tim.2015.10.001. Epub 2015 Oct 29.

DOI:10.1016/j.tim.2015.10.001
PMID:26526503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4698092/
Abstract

The proteasome system of Mycobacterium tuberculosis is required for causing disease. Proteasomes are multisubunit chambered proteases and, until recently, were only known to participate in adenosine triphosphate (ATP)-dependent proteolysis in bacteria. In this review, we discuss the latest advances in understanding how both ATP-dependent and ATP-independent proteasome-regulated pathways contribute to M. tuberculosis virulence.

摘要

结核分枝杆菌的蛋白酶体系统是致病所必需的。蛋白酶体是多亚基的腔室蛋白酶，直到最近，人们才知道它仅参与细菌中依赖三磷酸腺苷（ATP）的蛋白水解过程。在这篇综述中，我们讨论了在理解依赖ATP和不依赖ATP的蛋白酶体调节途径如何促进结核分枝杆菌毒力方面的最新进展。

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本文引用的文献

1
An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis.一种不依赖三磷酸腺苷的蛋白酶体激活剂有助于结核分枝杆菌的毒力。
Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1763-72. doi: 10.1073/pnas.1423319112. Epub 2015 Mar 23.
2
Caught in action: selecting peptide aptamers against intrinsically disordered proteins in live cells.实时捕捉：在活细胞中筛选针对内在无序蛋白质的肽适配体
Sci Rep. 2015 Mar 24;5:9402. doi: 10.1038/srep09402.
3
Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide.蛋白酶体对细胞分裂素合成的调控保护结核分枝杆菌抵御一氧化氮。
Mol Cell. 2015 Mar 19;57(6):984-994. doi: 10.1016/j.molcel.2015.01.024. Epub 2015 Feb 26.
4
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Cell. 2014 Dec 18;159(7):1497-509. doi: 10.1016/j.cell.2014.11.024.
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Bacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome.细菌蛋白酶体激活剂bpa（rv3780）是一种新型的分枝杆菌蛋白酶体环状相互作用蛋白。
PLoS One. 2014 Dec 3;9(12):e114348. doi: 10.1371/journal.pone.0114348. eCollection 2014.
6
Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation.分枝杆菌的存活依赖于营养限制下蛋白酶体介导的氨基酸再循环。
EMBO J. 2014 Aug 18;33(16):1802-14. doi: 10.15252/embj.201387076. Epub 2014 Jul 1.
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