“某些物质”的博弈：蛋白质破坏与结核分枝杆菌致病机制
Game of 'Somes: Protein Destruction for Mycobacterium tuberculosis Pathogenesis.
作者信息
Samanovic Marie I, Darwin K Heran
机构信息
New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236 New York, NY 10016, USA.
New York University School of Medicine, Department of Microbiology, 550 First Avenue, MSB 236 New York, NY 10016, USA.
出版信息
Trends Microbiol. 2016 Jan;24(1):26-34. doi: 10.1016/j.tim.2015.10.001. Epub 2015 Oct 29.
Abstract
The proteasome system of Mycobacterium tuberculosis is required for causing disease. Proteasomes are multisubunit chambered proteases and, until recently, were only known to participate in adenosine triphosphate (ATP)-dependent proteolysis in bacteria. In this review, we discuss the latest advances in understanding how both ATP-dependent and ATP-independent proteasome-regulated pathways contribute to M. tuberculosis virulence.
摘要
结核分枝杆菌的蛋白酶体系统是致病所必需的。蛋白酶体是多亚基的腔室蛋白酶，直到最近，人们才知道它仅参与细菌中依赖三磷酸腺苷（ATP）的蛋白水解过程。在这篇综述中，我们讨论了在理解依赖ATP和不依赖ATP的蛋白酶体调节途径如何促进结核分枝杆菌毒力方面的最新进展。
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