Jastrab Jordan B, Darwin K Heran
Department of Microbiology, New York University School of Medicine, New York, NY 10016; email:
Annu Rev Microbiol. 2015;69:109-27. doi: 10.1146/annurev-micro-091014-104201.
Interest in bacterial proteasomes was sparked by the discovery that proteasomal degradation is required for the pathogenesis of Mycobacterium tuberculosis, one of the world's deadliest pathogens. Although bacterial proteasomes are structurally similar to their eukaryotic and archaeal homologs, there are key differences in their mechanisms of assembly, activation, and substrate targeting for degradation. In this article, we compare and contrast bacterial proteasomes with their archaeal and eukaryotic counterparts, and we discuss recent advances in our understanding of how bacterial proteasomes function to influence microbial physiology.
对细菌蛋白酶体的兴趣源于一项发现，即蛋白酶体降解是世界上最致命的病原体之一——结核分枝杆菌发病机制所必需的。尽管细菌蛋白酶体在结构上与其真核生物和古细菌的同源物相似，但它们在组装、激活和底物靶向降解机制方面存在关键差异。在本文中，我们将细菌蛋白酶体与其古细菌和真核生物的对应物进行比较和对比，并讨论我们对细菌蛋白酶体如何发挥作用影响微生物生理学的最新认识进展。
