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牛奶代谢产物与神经退行性变:它们之间存在相互作用吗?

Milk metabolites and neurodegeneration: Is there crosstalk?

作者信息

Thakur Keshav, Anand Akshay

机构信息

Neuroscience Research Lab, Department of Neurology, PGIMER, Chandigarh, INDIA.

出版信息

Ann Neurosci. 2015 Oct;22(4):239-43. doi: 10.5214/ans.0972.7531.220410.

DOI:10.5214/ans.0972.7531.220410
PMID:26526864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4627205/
Abstract

Milk has been considered as a natural source of nutrition for decades. Milk is known to be nutrient-rich which aids the growth and development of the human body. Milk contains both macro- and micronutrients. Breast milk is widely regarded as the optimal source of neonatal nutrition due to its composition of carbohydrates, proteins, minerals and antibodies. However, despite the wide use of milk products, investigations into the role of milk in degenerative diseases have been limited. This review will examine the relationship between the β-casein gene found in bovine milk and disease states by using age-related macular degeneration as an example.

摘要

几十年来,牛奶一直被视为一种天然的营养来源。众所周知,牛奶富含营养,有助于人体的生长发育。牛奶含有大量营养素和微量营养素。母乳因其碳水化合物、蛋白质、矿物质和抗体的成分,被广泛认为是新生儿营养的最佳来源。然而,尽管乳制品的使用广泛,但关于牛奶在退行性疾病中的作用的研究却很有限。本综述将以年龄相关性黄斑变性为例,探讨牛奶中发现的β-酪蛋白基因与疾病状态之间的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf13/4627205/15e05f1fe3ad/ANS0972-7531-22-239-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf13/4627205/15e05f1fe3ad/ANS0972-7531-22-239-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf13/4627205/15e05f1fe3ad/ANS0972-7531-22-239-g002.jpg

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Milk metabolites and neurodegeneration: Is there crosstalk?牛奶代谢产物与神经退行性变:它们之间存在相互作用吗?
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本文引用的文献

1
In vitro digestion of purified β-casein variants A(1), A(2), B, and I: effects on antioxidant and angiotensin-converting enzyme inhibitory capacity.纯化的β-酪蛋白变体A(1)、A(2)、B和I的体外消化:对抗氧化和血管紧张素转换酶抑制能力的影响。
J Dairy Sci. 2015 Jan;98(1):15-26. doi: 10.3168/jds.2014-8330. Epub 2014 Nov 14.
2
An evolutionarily conserved non-coding element in casein locus acts as transcriptional repressor.酪蛋白基因座中一个进化上保守的非编码元件作为转录抑制子。
Gene. 2015 Jan 1;554(1):75-80. doi: 10.1016/j.gene.2014.10.026. Epub 2014 Oct 13.
3
The role of casein-specific IgA and TGF-β in children with food protein-induced enterocolitis syndrome to milk.
酪蛋白特异性IgA和转化生长因子-β在牛奶蛋白诱导的小肠结肠炎综合征患儿中的作用。
Pediatr Allergy Immunol. 2014 Nov;25(7):651-6. doi: 10.1111/pai.12288. Epub 2014 Nov 21.
4
Dietary A1 β-casein affects gastrointestinal transit time, dipeptidyl peptidase-4 activity, and inflammatory status relative to A2 β-casein in Wistar rats.与A2 β-酪蛋白相比,膳食A1 β-酪蛋白会影响Wistar大鼠的胃肠运输时间、二肽基肽酶-4活性和炎症状态。
Int J Food Sci Nutr. 2014 Sep;65(6):720-7. doi: 10.3109/09637486.2014.898260. Epub 2014 Mar 20.
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ALS and oxidative stress: the neurovascular scenario.肌萎缩侧索硬化症与氧化应激:神经血管机制。
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6
In vitro digestibility of bovine β-casein with simulated and human oral and gastrointestinal fluids. Identification and IgE-reactivity of the resultant peptides.牛 β-酪蛋白在模拟的和人体口腔及胃肠道液中的体外消化率。所得肽的鉴定和 IgE 反应性。
Food Chem. 2014 Jan 15;143:514-21. doi: 10.1016/j.foodchem.2013.07.110. Epub 2013 Jul 30.
7
Association between the cholesteryl ester transfer protein gene and polypoidal choroidal vasculopathy.载脂蛋白 E 基因多态性与脑梗死相关性的研究
Invest Ophthalmol Vis Sci. 2013 Sep 9;54(9):6068-73. doi: 10.1167/iovs.13-11605.
8
Apolipoprotein E gene variants as a risk factor for coronary artery disease in type 2 diabetic Egyptian patients.载脂蛋白E基因变异作为埃及2型糖尿病患者冠状动脉疾病的危险因素
Egypt J Immunol. 2012;19(1):1-10.
9
The role of DPP4 activity in cardiovascular districts: in vivo and in vitro evidence.二肽基肽酶 4 活性在心血管领域的作用:体内和体外证据。
J Diabetes Res. 2013;2013:590456. doi: 10.1155/2013/590456. Epub 2013 Jun 18.
10
CC chemokine receptor-3 as new target for age-related macular degeneration.CC 趋化因子受体-3 作为与年龄相关的黄斑变性的新靶点。
Gene. 2013 Jul 1;523(1):106-11. doi: 10.1016/j.gene.2013.03.052. Epub 2013 Apr 6.