Kaplan Merve, Baydemir Barış, Günar Bilgetekin Burak, Arslan Ayşenur, Duman Hatice, Karav Sercan
Department of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Department of Coaching Education, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Front Nutr. 2022 Jul 13;9:935344. doi: 10.3389/fnut.2022.935344. eCollection 2022.
Bovine milk is one of the best pre-and pro-workout sources for athletes owing to its rich nutritional content. Even though bovine milk consumption significantly benefits athletes' health and performance, many athletes cannot consume bovine milk since they struggle with gastrointestinal problems caused after milk consumption. Especially, the consumption of regular milk, which contains A1 β-casein, is associated with a variety of diseases ranging from gastrointestinal discomfort to ischemic heart diseases. The main reason behind this is related to β-casomorphine 7 (BCM-7), which is derived from A1 β-casein during the digestion of A1 milk. A1 β-casein is formed as a result of a point mutation in the position of 67 in the amino acid sequence A2 β-casein by changing proline to histidine. Therefore, this mutated form of β-casein in regular milk cannot easily be digested by the human-associated digestion enzymes. A2 milk, which includes A2 β-casein instead of A1 β-casein, is the best substitute for regular milk with the same nutritional content. This natural form of milk positively affects the athlete's health as well as performance without causing any gastrointestinal discomfort or more serious problems which are seen in the consumption of regular milk. In this review, A2 milk and its potential health effects in comparison to diseases related to A1 milk consumption are discussed.
由于其丰富的营养成分,牛奶是运动员最佳的运动前和运动后营养来源之一。尽管饮用牛奶对运动员的健康和表现有显著益处,但许多运动员无法饮用牛奶,因为他们在饮用牛奶后会出现胃肠道问题。特别是,含有A1 β-酪蛋白的普通牛奶的饮用与从胃肠道不适到缺血性心脏病等多种疾病有关。其背后的主要原因与β-酪蛋白吗啡7(BCM-7)有关,它是在A1牛奶消化过程中由A1 β-酪蛋白衍生而来的。A1 β-酪蛋白是由于氨基酸序列A2 β-酪蛋白中第67位的脯氨酸突变为组氨酸而形成的。因此,普通牛奶中这种突变形式的β-酪蛋白不易被人体相关消化酶消化。含有A2 β-酪蛋白而非A1 β-酪蛋白的A2牛奶是营养成分相同的普通牛奶的最佳替代品。这种天然形式的牛奶对运动员的健康和表现有积极影响,不会像饮用普通牛奶那样引起任何胃肠道不适或更严重的问题。在这篇综述中,将讨论A2牛奶及其与饮用A1牛奶相关疾病相比的潜在健康影响。