支链氨基酸对生长大鼠后肢悬吊诱导的肌肉萎缩的保护作用。
Protective effect of branched chain amino acids on hindlimb suspension-induced muscle atrophy in growing rats.
作者信息
Jang Jiwoong, Yun Hea-Yeon, Park Jonghoon, Lim Kiwon
机构信息
Laboratory of Exercise Nutrition, Department of Physical Education, Konkuk University, Seoul, Republic of Korea.
Physical Activity and Performance Institute (PAPI), Konkuk University, Seoul, Republic of Korea.
出版信息
J Exerc Nutrition Biochem. 2015 Sep;19(3):183-9. doi: 10.5717/jenb.2015.15062704. Epub 2015 Jul 31.
PURPOSE
The effect of BCAA (branched chain amino acid) administration on muscle atrophy during growth phases is not well known. We investigated whether BCAA administration can prevent the muscle atrophy induced by hindlimb suspension in growing male rats.
METHODS
Male Wistar rats were assigned to 1 of 2 groups (n = 7/group): hindlimb suspension and hindlimb suspension with oral BCAA administration (600 mg·kg(-1)·day(-1), valine 1: leucine 2: isoleucine 1). After 14 days of hindlimb suspension, the weight and mRNA levels of the soleus muscle were measured.
RESULTS
BCAA administration prevented a decrease in soleus muscle weight. BCAA administration attenuated atrogin-1 and MuRF1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy.
CONCLUSION
BCAA could serve as an effective supplement for the prevention or treatment of muscle atrophy, especially atrophy caused by weightlessness.
目的
支链氨基酸（BCAA）给药对生长阶段肌肉萎缩的影响尚不清楚。我们研究了BCAA给药是否能预防生长中雄性大鼠后肢悬吊诱导的肌肉萎缩。
方法
将雄性Wistar大鼠分为2组中的1组（每组n = 7）：后肢悬吊组和后肢悬吊并口服BCAA组（600 mg·kg⁻¹·天⁻¹，缬氨酸1：亮氨酸2：异亮氨酸1）。后肢悬吊14天后，测量比目鱼肌的重量和mRNA水平。
结果
BCAA给药可防止比目鱼肌重量下降。BCAA给药减弱了atrogin-1和MuRF1 mRNA的表达，据报道这两种基因在肌肉萎缩中起关键作用。
结论
BCAA可作为预防或治疗肌肉萎缩，尤其是失重引起的萎缩的有效补充剂。
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