Ip Stephen, Jeong Rachel, Schaeffer David F, Yoshida Eric M
Stephen Ip, Eric M Yoshida, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.
World J Hepatol. 2015 Oct 28;7(24):2559-62. doi: 10.4254/wjh.v7.i24.2559.
Glucosamine (GS) and chondroitin sulfate (CS) are common over-the-counter (OTC) supplements used in the treatment of osteoarthritis. These medications are seemingly safe, but there are increasing reports of hepatotoxicity with these supplements. We reported a unique case of drug-induced cholestasis caused by GS and CS in a combination tablet. The etiology of the jaundice was overlooked despite extensive investigations over a three-month period. Unlike drug-induced hepatocellular injury, drug-induced cholestatic jaundice with GS and CS has only been reported twice before. This case emphasizes the importance of a complete medication history, especially OTC supplements, in the assessment of cholestasis.
氨基葡萄糖（GS）和硫酸软骨素（CS）是用于治疗骨关节炎的常见非处方（OTC）补充剂。这些药物看似安全，但关于这些补充剂导致肝毒性的报道越来越多。我们报告了一例由GS和CS复方片剂引起的药物性胆汁淤积的独特病例。尽管在三个月的时间里进行了广泛的调查，但黄疸的病因仍被忽视。与药物性肝细胞损伤不同，GS和CS引起的药物性胆汁淤积性黄疸此前仅被报道过两次。该病例强调了完整用药史的重要性，尤其是非处方补充剂，在胆汁淤积评估中。
