Iwata Kentaro, Mizuno Yasushi
Division of Infectious Diseases, Kobe University Hospital, Kobe, Japan.
Department of General Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Int J Gen Med. 2015 Oct 21;8:345-7. doi: 10.2147/IJGM.S92435. eCollection 2015.
Polymyalgia rheumatica (PMR) is relatively common among the elderly, and is characterized by multiple body aches with an elevated erythrocyte sedimentation rate. Even though the etiology of PMR remains unknown, a number of infectious agents have been suggested to cause PMR. Also, there are reports of PMR after influenza vaccination. The exact role of influenza vaccination on the development of PMR remains unknown, but may be associated with specific human leukocyte antigens (HLAs), such as HLA-DRB1 and HLA-DQB1. Whether postvaccination PMR is caused by influenza virus antigen or adjuvants in the vaccine is another unanswered question. We herein report a case of an 85-year-old woman who developed PMR shortly after contracting influenza virus B. Even though infections are hypothesized to be one of the causes of PMR, this is the first-ever case of PMR following influenza virus infection. Further studies may elucidate the exact role of influenza virus infection on the etiology and pathogenesis of PMR.
风湿性多肌痛（PMR）在老年人中相对常见，其特征为全身多处疼痛且红细胞沉降率升高。尽管PMR的病因尚不清楚，但已有多种感染因子被认为可能导致PMR。此外，也有流感疫苗接种后发生PMR的报道。流感疫苗接种在PMR发病过程中的确切作用尚不清楚，但可能与特定的人类白细胞抗原（HLA）有关，如HLA - DRB1和HLA - DQB1。接种疫苗后发生的PMR是由流感病毒抗原还是疫苗中的佐剂引起，这是另一个尚未解决的问题。我们在此报告一例85岁女性病例，该患者在感染乙型流感病毒后不久就患上了PMR。尽管感染被认为是PMR的病因之一，但这是首例流感病毒感染后发生PMR的病例。进一步的研究可能会阐明流感病毒感染在PMR病因和发病机制中的确切作用。
