Department of Neurology, Fukuoka University School of Medicine, Japan.
Intern Med. 2022 Jun 1;61(11):1775-1777. doi: 10.2169/internalmedicine.8934-21. Epub 2022 Mar 26.
We herein report a 71-year-old woman presented with a fever, arthralgia, general malaise and leg muscle stiffness following administration of the COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). Laboratory findings showed an elevated C-reactive protein level and erythrocyte sedimentation rate. In addition, Gallium-67 scintigraphy demonstrated an increased uptake in multiple joints. Typing of human leukocyte antigen (HLA) revealed the presence of the DRB1*0404/*0803 allele. These findings met the diagnostic criteria for polymyalgia rheumatica (PMR), and when we started steroid treatment, her symptoms improved rapidly. This patient developed PMR after receiving a COVID-19 mRNA vaccine (Comirnaty, Pfizer-BioNTech). This case is considered to be valuable, as the HLA-DRB1 allele was also confirmed.
我们在此报告一例 71 岁女性，在接种 COVID-19 mRNA 疫苗（辉瑞-生物科技的 Comirnaty）后出现发热、关节痛、全身不适和腿部肌肉僵硬。实验室检查显示 C 反应蛋白水平和红细胞沉降率升高。此外，镓-67 闪烁扫描显示多个关节摄取增加。人类白细胞抗原（HLA）分型显示存在 DRB1*0404/*0803 等位基因。这些发现符合巨细胞动脉炎（PMR）的诊断标准，当我们开始使用类固醇治疗时，她的症状迅速改善。这名患者在接种 COVID-19 mRNA 疫苗（辉瑞-生物科技的 Comirnaty）后发生 PMR。由于还确认了 HLA-DRB1 等位基因，因此该病例被认为具有重要价值。
