精神分裂症中基底神经节网络整合的改变
Altered Basal Ganglia Network Integration in Schizophrenia.
作者信息
Duan Mingjun, Chen Xi, He Hui, Jiang Yuchao, Jiang Sisi, Xie Qiankun, Lai Yongxiu, Luo Cheng, Yao Dezhong
机构信息
Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China , Chengdu , China ; The Fourth People's Hospital of Chengdu , Chengdu , China.
Key Laboratory for NeuroInformation of Ministry of Education, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China , Chengdu , China.
出版信息
Front Hum Neurosci. 2015 Oct 12;9:561. doi: 10.3389/fnhum.2015.00561. eCollection 2015.
UNLABELLED
The basal ganglia involve in a range of functions that are disturbed in schizophrenia patients. This study decomposed the resting-state data of 28 schizophrenia patients and 31 healthy controls with spatial independent component analysis and identified increased functional integration in the bilateral caudate nucleus in schizophrenia patients. Further, the caudate nucleus in patients showed altered functional connection with the prefrontal area and cerebellum. These results identified the importance of basal ganglia in schizophrenia patients.
CLINICAL TRIAL REGISTRATION
Chinese Clinical Trial Registry. Registration number ChiCTR-RCS-14004878.
未标注
基底神经节参与一系列在精神分裂症患者中受到干扰的功能。本研究通过空间独立成分分析分解了28例精神分裂症患者和31例健康对照的静息态数据，发现精神分裂症患者双侧尾状核的功能整合增加。此外，患者的尾状核与前额叶区域和小脑的功能连接发生了改变。这些结果确定了基底神经节在精神分裂症患者中的重要性。
临床试验注册
中国临床试验注册中心。注册号：ChiCTR-RCS-14004878。
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