维生素D在炎症性肠病骨代谢病理学中的重要性。
The importance of vitamin D in the pathology of bone metabolism in inflammatory bowel diseases.
作者信息
Krela-Kaźmierczak Iwona, Szymczak Aleksandra, Łykowska-Szuber Liliana, Eder Piotr, Stawczyk-Eder Kamila, Klimczak Katarzyna, Linke Krzysztof, Horst-Sikorska Wanda
机构信息
Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.
Department of Family Medicine, Poznan University of Medical Sciences, Poznan, Poland.
出版信息
Arch Med Sci. 2015 Oct 12;11(5):1028-32. doi: 10.5114/aoms.2015.54858.
Etiological factors of bone metabolism disorders in inflammatory bowel diseases have been the subject of interest of many researchers. One of the questions often raised is vitamin D deficiency. Calcitriol acts on cells, tissues and organs through a vitamin D receptor. The result of this action is the multi-directional effect of vitamin D. The reasons for vitamin D deficiency are: decreased exposure to sunlight, inadequate diet, inflammatory lesions of the intestinal mucosa and post-gastrointestinal resection states. This leads not only to osteomalacia but also to osteoporosis. Of significance may be the effect of vitamin D on the course of the disease itself, through modulation of the inflammatory mechanisms. It is also necessary to pay attention to the role of vitamin D in skeletal pathology in patients with inflammatory bowel diseases and thus take measures aimed at preventing and treating these disorders through the supplementation of vitamin D.
炎症性肠病中骨代谢紊乱的病因一直是许多研究人员关注的课题。经常被提及的问题之一是维生素D缺乏。骨化三醇通过维生素D受体作用于细胞、组织和器官。这种作用的结果是维生素D的多向效应。维生素D缺乏的原因包括：日照减少、饮食不足、肠道黏膜炎症性病变以及胃肠道切除术后状态。这不仅会导致骨软化症，还会导致骨质疏松症。维生素D通过调节炎症机制对疾病本身的进程产生影响，这一点可能具有重要意义。同样有必要关注维生素D在炎症性肠病患者骨骼病理中的作用，从而通过补充维生素D采取预防和治疗这些疾病的措施。
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