Department of Veterinary and Biomedical Science, The Center for Molecular Immunology and Infectious Disease, 115 Henning Bldg., The Pennsylvania State University, University Park, PA 16802, USA.
Arch Biochem Biophys. 2012 Jul 1;523(1):103-6. doi: 10.1016/j.abb.2011.11.001. Epub 2011 Nov 10.
It has now been more than 20years since the vitamin D receptor was identified in cells of the immune system. The immune system has now been established as an important target of vitamin D. Vitamin D receptor knockout and vitamin D deficient mice have a surplus of effector T cells that have been implicated in the pathology of multiple sclerosis (MS) and inflammatory bowel disease (IBD). The active form of vitamin D directly and indirectly suppresses the function of these pathogenic T cells while inducing several regulatory T cells that suppress MS and IBD development. There is reason to believe that vitamin D could be an environmental factor that may play a role in the development of these immune mediated diseases in the clinic but at present there has not been a causal relationship established. Nonetheless, current evidence suggests that improving vitamin D status and/or using vitamin D receptor agonists may be useful in MS and IBD.
自从免疫系统中的维生素 D 受体被发现以来，已经过去了 20 多年。免疫系统现已被确定为维生素 D 的重要靶标。维生素 D 受体敲除和维生素 D 缺乏的小鼠具有过量的效应 T 细胞，这些细胞与多发性硬化症 (MS) 和炎症性肠病 (IBD) 的病理学有关。维生素 D 的活性形式直接和间接地抑制这些致病性 T 细胞的功能，同时诱导几种调节性 T 细胞，抑制 MS 和 IBD 的发展。有理由相信，维生素 D 可能是一种环境因素，可能在这些免疫介导的疾病的临床发展中发挥作用，但目前尚未建立因果关系。尽管如此，目前的证据表明，改善维生素 D 状况和/或使用维生素 D 受体激动剂可能对 MS 和 IBD 有用。
