Nogi Keisuke, Fujihara Tetsuaki, Terao Jun, Tsuji Yasushi
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University , Nishikyo-ku, Kyoto 615-8510, Japan.
J Org Chem. 2015 Nov 20;80(22):11618-23. doi: 10.1021/acs.joc.5b02307. Epub 2015 Nov 11.
A highly efficient cobalt-catalyzed reductive carboxylation reaction of alkenyl trifluoromethanesulfonates (triflates) has been developed. By employing Mn powder as a reducing reagent under 1 atm pressure of CO2 at room temperature, diverse alkenyl triflates can be converted to the corresponding α,β-unsaturated carboxylic acids. Moreover, the carboxylation of sterically hindered aryl triflates proceeds smoothly in the presence of a nickel or cobalt catalyst.
已开发出一种高效的钴催化烯基三氟甲磺酸酯（三氟甲磺酸酯）的还原羧基化反应。通过在室温下于1个大气压的二氧化碳压力下使用锰粉作为还原剂，各种烯基三氟甲磺酸酯可转化为相应的α,β-不饱和羧酸。此外，在镍或钴催化剂存在下，空间位阻较大的芳基三氟甲磺酸酯的羧基化反应顺利进行。
