Selective C-F bond carboxylation of -difluoroalkenes with CO by photoredox/palladium dual catalysis.

The catalytic C-F bond carboxylation of organofluorines with CO gas remains a challenging problem in synthetic chemistry. Here, we describe a selective defluorinative carboxylation of -difluoroalkenes through photoredox/palladium dual catalysis. The C-F bond activation is enabled by single electron reduction through photoredox catalysis to generate a fluorovinyl radical, which subsequently participates in an unprecedented palladium-catalyzed carboxylation. This novel C-F functionalization proved applicable to a wide range of substituted -difluoroalkenes, providing a rapid access to valuable α-fluoroacrylic acids.