Lam B Y H, Yang Y, Raine A, Lee T M C
Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong, China.
Department of Pediatrics, Children's Hospitals Los Angeles, Keck School of Medicine, The University of Southern California, Los Angeles, CA, USA.
Transl Psychiatry. 2015 Nov 3;5(11):e669. doi: 10.1038/tp.2015.162.
Prior studies have established that schizotypal personality traits (schizotypy) were associated with antisocial behavior (crime), but it is unclear what neural factors mediate this relationship. This study assessed the mediating effect that sub-regional prefrontal gray, specifically the orbitofrontal gray matter volume, has on the schizotypy-antisocial behavior relationship. Five prefrontal sub-regional (superior, middle, inferior, orbitofrontal and rectal gyral) gray matter volumes were assessed using structural magnetic resonance imaging in 90 adults from the community, together with schizotypy and antisocial behavior. Among all five prefrontal sub-regions, the orbitofrontal cortex (OFC) was the major region-of-interest in the present study. Mediation analyses showed that orbitofrontal gray fully mediated the association between schizotypy and antisocial behavior. After having controlled the sex, age, socio-economic statuses, whole brain volumes and substance abuse/dependence of test subjects, the orbitofrontal gray still significantly mediated the effect of schizotypy on antisocial behavior by 53.5%. These findings are the first that document a neural mediator of the schizotypy-antisocial behavior relationship. Findings also suggest that functions subserved by the OFC, including impulse control and inhibition, emotion processing and decision-making, may contribute to the above comorbidity.
先前的研究已经证实，分裂型人格特质（分裂型人格）与反社会行为（犯罪）有关，但尚不清楚哪些神经因素介导了这种关系。本研究评估了前额叶灰质亚区域，特别是眶额灰质体积，对分裂型人格与反社会行为关系的中介作用。使用结构磁共振成像对90名社区成年人的五个前额叶亚区域（额上回、额中回、额下回、眶额回和直回）的灰质体积进行了评估，并同时评估了他们的分裂型人格和反社会行为。在所有五个前额叶亚区域中，眶额皮质（OFC）是本研究的主要感兴趣区域。中介分析表明，眶额灰质完全介导了分裂型人格与反社会行为之间的关联。在控制了测试对象的性别、年龄、社会经济地位、全脑体积以及药物滥用/依赖情况后，眶额灰质仍能显著介导分裂型人格对反社会行为53.5%的影响。这些发现首次记录了分裂型人格与反社会行为关系的神经中介因素。研究结果还表明，眶额皮质所支持的功能，包括冲动控制与抑制、情绪处理和决策，可能导致了上述共病现象。
