Kratz Anna L, Ehde Dawn M, Hanley Marisol A, Jensen Mark P, Osborne Travis L, Kraft George H
Department of Physical Medicine and Rehabilitation Medicine, University of Michigan, Ann Arbor, MI.
Department of Rehabilitation Medicine, University of Washington, Seattle, WA.
Arch Phys Med Rehabil. 2016 Mar;97(3):386-94. doi: 10.1016/j.apmr.2015.10.093. Epub 2015 Oct 31.
To determine the frequency and severity of 8 symptoms in persons with multiple sclerosis (MS) and to examine the association between these symptoms and community integration and mental health.
Cross-sectional survey that assessed 8 symptoms (pain, fatigue, imbalance, numbness, weakness, shortness of breath, vision loss, and memory loss), disease progression (self-report version of the Expanded Disability Status Scale), community integration, and mental health.
Community.
Adults with self-reported MS who responded to a mailed survey (N=180).
Not applicable.
The presence and intensity of symptoms were measured with a symptoms checklist. Community integration was assessed with the Community Integration Questionnaire, and mental health was measured by the Mental Health Index of the Medical Outcomes Study 36-Item Short-Form Health Survey.
The average number of symptoms reported was 5.07±2.18. The most common symptoms (fatigue, weakness, and imbalance) were also rated as the most severe. Not all symptoms were associated with level of disease progression or with MS subtype. Symptoms related to mobility were more likely to be associated with these variables. The 8 symptoms as a whole accounted for significant amounts of variance (range, 13%-21%) in measures of community integration and mental health, with specific symptoms making differential independent contributions to these measures.
This study demonstrates that most individuals with MS report a number of bothersome symptoms. Type of MS or level of progression does not tell the whole story regarding the impact of symptoms.
确定多发性硬化症（MS）患者8种症状的发生频率和严重程度，并研究这些症状与社区融入及心理健康之间的关联。
横断面调查，评估8种症状（疼痛、疲劳、失衡、麻木、虚弱、呼吸急促、视力丧失和记忆力丧失）、疾病进展（扩展残疾状态量表自我报告版）、社区融入和心理健康。
社区。
对邮寄调查问卷做出回应的自我报告患有MS的成年人（N = 180）。
不适用。
使用症状清单测量症状的存在和强度。用社区融入问卷评估社区融入情况，通过医学结局研究36项简短健康调查的心理健康指数测量心理健康状况。
报告的症状平均数量为5.07±2.18。最常见的症状（疲劳、虚弱和失衡）也被评为最严重的症状。并非所有症状都与疾病进展程度或MS亚型相关。与活动能力相关的症状更有可能与这些变量相关。这8种症状总体上在社区融入和心理健康测量中占显著比例的方差（范围为13% - 21%），特定症状对这些测量有不同的独立贡献。
本研究表明，大多数MS患者报告有多种困扰症状。MS的类型或进展程度并不能完全说明症状的影响。
