Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.
Mult Scler. 2012 May;18(5):639-46. doi: 10.1177/1352458511426736. Epub 2011 Oct 7.
Multiple sclerosis has a vast impact on health, but the relationship between walking, manual dexterity, cognition and activity/participation is unclear.
The specific aims were to explore the discriminative ability of measures of walking, manual dexterity and cognition, and to identify cut-off values in these measures, for prediction of independence in personal and instrumental activities of daily living (ADL) and activity/participation in social and lifestyle activities.
Data from 164 persons with multiple sclerosis were collected during home visits with the following measures: the 2 × 5 m walk test, the Nine-hole Peg Test, the Symbol Digit Modalities Test, the Katz Personal and Instrumental ADL Indexes, and the Frenchay Activities Index (measuring frequency in social and lifestyle activities).
The 2 × 5 m walk test and the Nine-hole Peg Test had high and better discriminative and predictive ability than the Symbol Digit Modalities Test. Cut-off values were identified. The accuracy of predictions was increased above all by combining the 2 × 5 m walk test and the Nine-hole Peg Test.
The proposed cut-off values in the 2 × 5 m walk test and the Nine-hole Peg Test may be used as indicators of functioning and to identify persons risking activity limitations and participation restrictions. However, further studies are needed to confirm the usefulness in clinical practice.
多发性硬化症对健康有很大的影响，但行走、手灵巧度、认知与活动/参与之间的关系尚不清楚。
本研究的具体目的是探讨行走、手灵巧度和认知测量的区分能力，并确定这些测量指标的截断值，以预测个人和工具性日常生活活动（ADL）以及社会和生活方式活动中的活动/参与的独立性。
在家访中收集了 164 名多发性硬化症患者的数据，使用以下测量方法：2 × 5 米步行测试、九孔钉测试、符号数字模态测试、Katz 个人和工具性 ADL 指数以及 Frenchay 活动指数（测量社会和生活方式活动的频率）。
2 × 5 米步行测试和九孔钉测试的区分能力和预测能力均较高且优于符号数字模态测试。确定了截断值。通过结合 2 × 5 米步行测试和九孔钉测试，预测的准确性得到了提高。
2 × 5 米步行测试和九孔钉测试中的建议截断值可作为功能指标，并识别出有活动受限和参与受限风险的患者。然而，还需要进一步的研究来确认其在临床实践中的有用性。
