Balodis Iris M, Grilo Carlos M, Potenza Marc N
1Department of Psychiatry,Yale University School of Medicine,New Haven,Connecticut,USA.
CNS Spectr. 2015 Dec;20(6):557-65. doi: 10.1017/S1092852915000814. Epub 2015 Nov 4.
Biobehavioral features associated with binge-eating disorder (BED) have been investigated; however, few systematic reviews to date have described neuroimaging findings from studies of BED. Emerging functional and structural studies support BED as having unique and overlapping neural features as compared with other disorders. Neuroimaging studies provide evidence linking heightened responses to palatable food cues with prefrontal areas, particularly the orbitofrontal cortex (OFC), with specific relationships to hunger and reward-sensitivity measures. While few studies to date have investigated non-food-cue responses; these suggest a generalized hypofunctioning in frontostriatal areas during reward and inhibitory control processes. Early studies applying neuroimaging to treatment efforts suggest that targeting neural function underlying motivational processes may prove important in the treatment of BED.
与暴饮暴食症（BED）相关的生物行为特征已得到研究；然而，迄今为止，很少有系统综述描述过关于BED研究的神经影像学结果。新出现的功能和结构研究表明，与其他疾病相比，BED具有独特且重叠的神经特征。神经影像学研究提供了证据，将对美味食物线索的增强反应与前额叶区域，特别是眶额皮质（OFC）联系起来，这与饥饿和奖励敏感性测量存在特定关系。虽然迄今为止很少有研究调查非食物线索反应；但这些研究表明，在奖励和抑制控制过程中，额纹状体区域普遍存在功能减退。早期将神经影像学应用于治疗的研究表明，针对动机过程背后的神经功能可能在BED的治疗中被证明是重要的。
