School of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Victoria 3800, Australia.
Curr Pharm Des. 2020;26(20):2327-2333. doi: 10.2174/1381612826666200309152321.
People with Binge Eating Disorder (BED) exhibit heightened sensitivity to rewarding stimuli and elevated activity in reward-related brain regions, including the orbitofrontal cortex (OFC), ventral striatum (VS) and insula, during food-cue exposure. BED has also been associated with altered patterns of functional connectivity during resting-state. Investigating neural connectivity in the absence of task stimuli provides knowledge about baseline communication patterns that may influence the behavioural and cognitive manifestation of BED. Elevated resting-state functional connectivity (rsFC) between reward-related brain regions may contribute to uncontrolled eating bouts observed in BED, through heightened food-cue sensitivity and food-craving. The impact of homeostatic state on rsFC of the reward system has not yet been investigated in people with BED. Homeostatic dysfunction is a key driver of excessive food consumption in obesity, whereby rsFC between rewardrelated brain regions does not attenuate during satiety. Future studies should investigate BED related differences in rsFC within the reward system during hunger and satiety, in order to determine whether individuals with BED display an abnormal neural response to changes in homeostatic state. This knowledge would further enhance current understandings of the mechanisms contributing to BED, potentially implicating both reward and homeostatic dysfunctions as drivers of BED.
暴食症患者（BED）在暴露于食物线索时，表现出对奖励刺激的高度敏感，以及奖励相关脑区（包括眶额皮层（OFC）、腹侧纹状体（VS）和岛叶）的活动增强。BED 还与静息状态下功能连接模式的改变有关。在没有任务刺激的情况下研究神经连接，可以提供关于基线通讯模式的知识，这些模式可能会影响 BED 的行为和认知表现。奖励相关脑区之间静息状态功能连接（rsFC）的升高，可能通过增强食物线索敏感性和食欲，导致 BED 中观察到的无法控制的进食发作。静息状态下奖励系统的 rsFC 与稳态状态的关系尚未在 BED 患者中进行研究。稳态功能障碍是肥胖症过度进食的关键驱动因素，在饱腹感期间，奖励相关脑区之间的 rsFC 不会减弱。未来的研究应该在饥饿和饱腹感期间，调查 BED 相关的奖励系统内 rsFC 的差异，以确定 BED 患者是否表现出对稳态变化的异常神经反应。这些知识将进一步增强对导致 BED 的机制的理解，可能将奖励和稳态功能障碍都作为 BED 的驱动因素。
