使用手性、空气稳定的伯膦进行锆催化的分子间氢膦化反应。
Zirconium-catalyzed intermolecular hydrophosphination using a chiral, air-stable primary phosphine.
作者信息
Bange Christine A, Ghebreab Michael B, Ficks Arne, Mucha Neil T, Higham Lee, Waterman Rory
机构信息
Department of Chemistry, University of Vermont, Cook Physical Sciences Building, Burlington, Vermont 05405, USA.
出版信息
Dalton Trans. 2016 Feb 7;45(5):1863-7. doi: 10.1039/c5dt03544a. Epub 2015 Oct 27.
Catalytic hydrophosphination of alkenes using a chiral, air-stable primary phosphine, (R)-[2'-methoxy(1,1'-binapthalen)-2-yl]phosphine, (R)-MeO-MOPH2, proceeds under mild conditions with a zirconium catalyst, [κ(5)-N,N,N,N,C-(Me3SiNCH2CH2)2NCH2CH2NSiMe2CH]Zr (1), to selectively furnish anti-Markovnikov, air-stable secondary phosphines or tertiary phosphines with slight modification of the protocol. An intermediate in the catalysis, [(N3N)Zr(R)-MeO-MOPH] (4), was structurally characterized.
使用手性、空气稳定的伯膦（R）-[2'-甲氧基（1,1'-联萘）-2-基]膦（R）-MeO-MOPH₂，在温和条件下，通过锆催化剂[κ(5)-N,N,N,N,C-(Me₃SiNCH₂CH₂)₂NCH₂CH₂NSiMe₂CH]Zr (1)对烯烃进行催化氢膦化反应，只需对反应方案稍作修改，就能选择性地生成反马氏规则、空气稳定的仲膦或叔膦。对催化过程中的中间体[(N₃N)Zr(R)-MeO-MOPH] (4)进行了结构表征。
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