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食言？催化氢膦化面临的持续挑战

Broken Promises? On the Continued Challenges Faced in Catalytic Hydrophosphination.

作者信息

Lau Samantha, Hood Thomas M, Webster Ruth L

机构信息

Department of Chemistry, University of Bath, Bath BA2 7AY, U.K.

出版信息

ACS Catal. 2022 Sep 2;12(17):10939-10949. doi: 10.1021/acscatal.2c03144. Epub 2022 Aug 22.

DOI:10.1021/acscatal.2c03144
PMID:36082053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9442583/
Abstract

In this Perspective, we discuss what we perceive to be the continued challenges faced in catalytic hydrophosphination chemistry. Currently the literature is dominated by catalysts, many of which are highly effective, that generate the same phosphorus architectures, e.g., anti-Markovnikov products from the reaction of activated alkenes and alkynes with diarylphosphines. We highlight the state of the art in stereoselective hydrophosphination and the scope and limitations of chemoselective hydrophosphination with primary phosphines and PH. We also highlight the progress in the chemistry of the heavier homologues. In general, we have tried to emphasize what is missing from our hydrophosphination armament, with the aim of guiding future research targets.

摘要

在这篇展望文章中，我们讨论了我们认为在催化氢膦化化学中持续面临的挑战。目前，文献中主要是催化剂，其中许多非常有效，它们生成相同的磷结构，例如，活性烯烃和炔烃与二芳基膦反应生成的反马氏产物。我们强调了立体选择性氢膦化的现状以及用伯膦和PH进行化学选择性氢膦化的范围和局限性。我们还强调了较重同系物化学方面的进展。总体而言，我们试图强调我们氢膦化手段中所缺少的东西，旨在指导未来的研究目标。

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